Arimoto, Masahiro published the artcileSemisynthetic β-lactam antibiotics. IV. Synthesis and antibacterial activity of 7β-[2-(hetero aromatic methoxyimino)-2-(2-aminothiazol-4-yl)acetamido]cephalosporins, Product Details of C5H8N2O, the publication is Journal of Antibiotics (1988), 41(12), 1795-811, database is CAplus and MEDLINE.
Title compounds I [R = OAc, 1-methyl-5-tetrazolylthio, (un)substituted pyridinium, 1-methylpyrrolidinium, pyridazinium; R1 = (un)substituted imidazol-4-yl, 1,2,3-triazol-4-yl, pyridazin-3-yl, pyrimidin-4-yl, pyrazinyl] were synthesized and bacteriol. evaluated. Several I showed exceptional in vitro activity. The most active derivative, I (R = pyridinium, R1 = imidazol-4-yl), was the most evenly balanced with respect to activity against Gram-pos. and Gran-neg. bacteria. Furthermore, I (R = pyridinium, R1 = imidazol-4-yl) was stable to various types of β-lactamases and had high affinities for penicillin binding protein-3 and -1Bs of both Escherichia coli and Pseudomonas aeruginosa.
Journal of Antibiotics published new progress about 45533-87-7. 45533-87-7 belongs to imidazoles-derivatives, auxiliary class Imidazole,Alcohol,Imidazole, name is (2-Methyl-1H-imidazol-4-yl)methanol, and the molecular formula is C5H8N2O, Product Details of C5H8N2O.
Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem