Zhang, Ling-chun’s team published research in Zhongguo Yiyuan Yaoxue Zazhi in 34 | CAS: 2508-72-7

Zhongguo Yiyuan Yaoxue Zazhi published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C11H12O4, Application of N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride.

Zhang, Ling-chun published the artcileDetermination of antazoline hydrochloride in rat plasma by HPLC and its application to pharmacokinetic study, Application of N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, the publication is Zhongguo Yiyuan Yaoxue Zazhi (2014), 34(17), 1456-1459, database is CAplus.

A HPLC method for the determination of antazoline hydrochloride in rat plasma was established and the pharmacokinetics of antazoline hydrochloride in rats were studied. A sensitive and specific HPLC method was developed and validated using phenacetin as the internal standard (IS). The analyte and the IS were extracted from rat by Et acetate under the basic condition. The analytes were separated by a C18 column and detected with a variable wavelength UV-detector. The mobile phase consisted of methanol-5 mmol L-1 tetra-Bu ammonium bromide (40:60) and the flow rate was 1.0ml·min-1. Standard calibration graph for antazoline hydrochloride was linear over a curve range of 50-4 000 ng·ml-1 (R=0.999 3) and the lower limit of quantification was 50 ng·ml-1 using a plasma sample of 100 μl. The intra-and inter-day precision values were less than 13.3% relative standard deviation (RSD). The intra-day and inter-day assay precision was in the range of ±15% and the accuracy in the range of 89.9%-110.6%. The extraction recoveries were on the average of 80% for antazoline hydrochloride and 75%for IS. After i. g. administration of antazoline hydrochloride, the major pharmacokinetic parameters were as follows: AUC0-t=(5.15±0.39) mg·h·L-1, AUCt-∞=(5.37±0.26) mg·h·L-1, t1/2=(3.91±0.88) h, CL=(1.86±0.09) L·kg-1·h-1, V=(8.07±2.51) L·kg-1, Cmax=(3.35±0.21) mg·L-1, tmax=(0.75±0.36) h. This method was successfully applied to pharmacokinetic studies of antazoline hydrochloride after ig administration to SD rats.

Zhongguo Yiyuan Yaoxue Zazhi published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C11H12O4, Application of N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem