Thoma, K. published the artcileColloid association of antihistamines. Part 1. Relation between chemical structure and critical micelle formation concentration, Quality Control of 2508-72-7, the publication is Pharmaceutica Acta Helvetiae (1976), 51(3), 50-8, database is CAplus and MEDLINE.
Surface tensions were determined for 17 antihistamines in 0.5% aqueous solutions, and critical micelle concentrations ranging from 0.012 mole/l. (medrylamine maleate [60407-52-5]) to 0.185 mole/l. (Thenfadil [91-79-2]) were determined for all of these compounds and also for chlorphenamine-HCl [56343-98-7] in 0.9% saline. Cryoscopic, spectrophotometric, tensiometric, potentiometric, and conductometric methods were used to determine the critical micelle concentrations, and the results and ease of use were compared. The unsubstituted ethylenediamine, propylamine, and ethanolamine derivatives, Pyribenzamine [91-81-6], Avil [3269-83-8], and Benadryl [147-24-0], had similar critical micelle concentrations These concentrations decreased on phenyl group substitution in the order Me > Cl > Br.
Pharmaceutica Acta Helvetiae published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C10H15ClO3S, Quality Control of 2508-72-7.
Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem