Smith, Leon M. II published the artcileNovel phenylalanine derived diamides as Factor XIa inhibitors, Application In Synthesis of 13682-33-2, the publication is Bioorganic & Medicinal Chemistry Letters (2016), 26(2), 472-478, database is CAplus and MEDLINE.
The synthesis, structural activity relationships (SAR), and selectivity profile of a potent series of phenylalanine diamide FXIa inhibitors will be discussed. Exploration of P1 prime and P2 prime groups led to the discovery of compounds with high FXIa affinity, good potency in our clotting assay (aPPT), and high selectivity against a panel of relevant serine proteases as exemplified by compound (I). Compound I demonstrated good in vivo efficacy (EC50 = 2.8 μM) in the rabbit elec. induced carotid arterial thrombosis model (ECAT).
Bioorganic & Medicinal Chemistry Letters published new progress about 13682-33-2. 13682-33-2 belongs to imidazoles-derivatives, auxiliary class Imidazole,Amine,Benzene, name is 4-(1H-Imidazol-2-yl)aniline, and the molecular formula is C10H9NO4S, Application In Synthesis of 13682-33-2.
Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem