San Andres, M. P. published the artcileDetermination of antihistamines based on the formation of mixed aggregates with surfactants, Related Products of imidazoles-derivatives, the publication is Analyst (Cambridge, United Kingdom) (1998), 123(5), 1079-1084, database is CAplus.
The determination of antihistamines based on the measurement of the critical micelle concentration (CMC) of mixed sodium dodecyl sulfate (SDS)-antihistamine aggregates is proposed. The dye Coomassie Brilliant Blue G (CBBG) was used as a photometric probe (610 nm) for the rapid determination of CMCs. The micellar properties of the drugs permitted the determination of diphenhydramine, antazoline, tripelennamine, diphenylpyraline, and clemizole at the μM level, with detection limits from 0.1 to 0.7 μM. The proposed method surpasses in sensitivity the existing routine photometric methods used in the drug quality control and has detection limits similar to fluorimetric methods. The relative standard deviation for 6 μM diphenhydramine was 3.7%. The method was applied to the determination of these drugs in pharmaceutical preparations (solutions, capsules, creams, pills) which were analyzed directly after dissolution in distilled water.
Analyst (Cambridge, United Kingdom) published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Related Products of imidazoles-derivatives.
Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem