Roberts, Fiona published the artcileThe kinetics of competitive antagonists on guinea-pig ileum, Quality Control of 2508-72-7, the publication is British Journal of Pharmacology (1976), 58(1), 57-70, database is CAplus and MEDLINE.
The kinetics of the antagonistic action of mepyramine maleate [59-33-6], atropine sulfate [55-48-1], lachesine [1164-38-1], benziloyltropine methyliodide [21735-94-4], pentyltriethyl ammonium iodide [21735-95-5], and antazoline-HCl [2508-72-7] on guinea pig isolated ileum were not consistent with the predictions of the interaction-limited model described by W. D. M. Paton (1961). The apparent dissociation rate constant calculated from the decrease in occupancy on washout was not independent of the concentration of antagonist; the dissociation rate constant of a ‘slow’ antagonist calculated from the change in occupancy when a ‘fast’ antagonist was superimposed varied with the concentration of fast antagonist; if the concentration of slow antagonist was increased when the fast antagonist was superimposed so that the equilibrium occupancy of the ‘slow’ was the same as before, a transitional phase was observed
British Journal of Pharmacology published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Quality Control of 2508-72-7.
Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem