Reddy, Vajrala Venkata published the artcileIdentification and synthesis of potential impurities of losartan potassium – a non-peptide angiotensinogen II receptor antagonist, COA of Formula: C8H13ClN2O, the publication is Asian Journal of Chemistry (2007), 19(5), 3789-3796, database is CAplus.
In the process for the preparation of losartan, identified four potential impurities ranging from 0.05-0.15 % were detected in HPLC. Based on the mass spectral data obtained by LC-MS anal. structure of these impurities were characterized as potassium salt of 2-n-butyl-5-chloro-4-hydroxymethyl-1-[(2′-(2H-tetrazole-5-yl)-1,1′-biphenyl-4-yl)methyl]-1H-imidazol (Imp-A, Isolosartan potassium), potassium salt of 5-(4′-methyl-1,1′-biphenyl-2yl)-2H-tetrazole (Imp-B, biphenyl tetrazole analog of 1), 2-butyl-4-chloro-1-2′-(1H-tetrazol-5-yl)-1,1′-biphenyl-4-ylmethyl-1H-imidazole-5-ethanoate (Imp-C, ester analog of losartan) and 2-n-butyl-4-chloro-1-2′-(1H-tetrazol-5-yl)-1,1′-biphenyl-4-yl-5-triphenyl methoxy methyl-1H-imidazole (Imp-D, o-trityl losartan). These impurities were synthesized from an unambiguous route, confirmed the structure by collecting various spectral data and co-injected with losartan, retention time is matching with expected impurities. To our knowledge the impurities A-D were not reported as process impurities elsewhere.
Asian Journal of Chemistry published new progress about 79047-41-9. 79047-41-9 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Alcohol, name is (2-Butyl-4-chloro-1H-imidazol-5-yl)methanol, and the molecular formula is C8H13ClN2O, COA of Formula: C8H13ClN2O.
Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem