Moore, Terry W. published the artcileSynthesis and Metabolic Studies of Host-Directed Inhibitors for Antiviral Therapy, Recommanded Product: 4-(1H-Benzo[d]imidazol-2-yl)-1,2,5-oxadiazol-3-amine, the publication is ACS Medicinal Chemistry Letters (2013), 4(8), 762-767, database is CAplus and MEDLINE.
Targeting host cell factors required for virus replication provides an alternative to targeting pathogen components and represents a promising approach to develop broad-spectrum antiviral therapeutics. High-throughput screening (HTS) identified two classes of inhibitors with broad-spectrum antiviral activity against ortho- and paramyxoviruses including influenza A virus (IAV), measles virus (MeV), respiratory syncytial virus (RSV), and human parainfluenza virus type 3 (HPIV3). Hit-to-lead optimization delivered inhibitor N-methyl-N-((1-methyl-4,5-diphenyl-1H-imidazol-2-yl)methyl)aniline, with EC50 values of 0.88 and 0.81 μM against IAV strain WSN and MeV strain Edmonston, resp. It was also found that N-methyl-N-((1-methyl-4,5-diphenyl-1H-imidazol-2-yl)methyl)aniline delivers good stability in human liver S9 fractions with a half-life of 165 min. These data establish N-methyl-N-((1-methyl-4,5-diphenyl-1H-imidazol-2-yl)methyl)aniline as a promising lead for antiviral therapy through a host-directed mechanism.
ACS Medicinal Chemistry Letters published new progress about 332026-86-5. 332026-86-5 belongs to imidazoles-derivatives, auxiliary class Oxadiazole,Amine,Benzimidazole, name is 4-(1H-Benzo[d]imidazol-2-yl)-1,2,5-oxadiazol-3-amine, and the molecular formula is C9H7N5O, Recommanded Product: 4-(1H-Benzo[d]imidazol-2-yl)-1,2,5-oxadiazol-3-amine.
Referemce:
https://en.wikipedia.org/wiki/Imidazole,
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