Jankowska-Anyszka, Marzena published the artcileSynthesis of a new class of ribose functionalized dinucleotide cap analogs for biophysical studies on interaction of cap-binding proteins with the 5′ end of mRNA, Synthetic Route of 359860-27-8, the publication is Organic & Biomolecular Chemistry (2011), 9(15), 5564-5572, database is CAplus and MEDLINE.
MRNAs of primitive eukaryotes such as Caenorhabditis elegans and Ascaris summ possess two different caps at their 5′ terminus. They have either a typical cap which consists of 7-methylguanosine linked via a 5′,5′-triphosphate bridge to the first transcribed nucleotide (MMG cap) or an atypical hypermethylated form with two addnl. Me groups at the N2 position (TMG cap). Studies on interaction between the 5′ end of mRNA and proteins that specifically recognize its structure have been carried out for several years and they often require chem. modified cap analogs. Here, we present the synthesis of five novel dinucleotide MMG and TMG cap analogs designed for binding studies using biophys. methods such as ESR and surface plasmon resonance. New analogs were prepared by derivatization of the 2′,3′-cis diol of the second nucleotide in the cap structure with levulinic acid, and coupling of the obtained acetal through its carboxylic group with 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl (4-amino TEMPO), ethylenediamine (EDA) or (+)-biotinyl-3,6,9-trioxaundecanediamine (amine-PEO3-biotin).
Organic & Biomolecular Chemistry published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Synthetic Route of 359860-27-8.
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Imidazole | C3H4N2 – PubChem