Housman, Seth T. published the artcilePhysical compatibility of telavancin hydrochloride with select i.v. drugs during simulated Y-site administration, Related Products of imidazoles-derivatives, the publication is American Journal of Health-System Pharmacy (2011), 68(23), 2265-2270, database is CAplus and MEDLINE.
The phys. compatibility of telavancin with select i.v. drugs during simulated Y-site administration was evaluated. Telavancin for injection was reconstituted according to manufacturer’s recommendations and diluted with 0.9% sodium chloride injection, 5% dextrose injection, or lactated Ringer’s injection to a concentration of 7.5 mg/mL. A Y site was simulated in culture tubes by mixing 5 mL of telavancin solution with 5 mL of a tested drug solution and then switching the order of drug mixing. All mixtures were prepared in duplicate and stored at room temperature Solutions were inspected for visual, turbidity, and pH changes immediately after preparation and 15, 60, and 120 min after preparation Of the 52 drugs tested, telavancin was phys. compatible with 39 drugs in all test solutions Telavancin was incompatible with amphotericin B deoxycholate, liposomal amphotericin B, digoxin, esomeprazole sodium, furosemide, levofloxacin, and micafungin sodium in all diluents. Colistimethate sodium, cyclosporine, heparin sodium, imipenem-cilastatin sodium, methylprednisolone sodium succinate, and propofol were incompatible with telavancin in specific diluents. Incompatibilities included precipitation, pos. Tyndall beam test, and increases in turbidity. There were no substantial changes in pH over the 120-min study period. Telavancin 7.5 mg/mL in 0.9% sodium chloride injection, 5% dextrose injection, and lactated Ringer’s injection was found to be phys. compatible for 120 min at room temperature with 39 of the 52 drugs tested during simulated Y-site administration. Seven drugs were incompatible in all diluents, and 6 were incompatible in at least one diluent.
American Journal of Health-System Pharmacy published new progress about 161796-78-7. 161796-78-7 belongs to imidazoles-derivatives, auxiliary class Membrane Transporter/Ion Channel,Proton Pump, name is Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, and the molecular formula is C17H18N3NaO3S, Related Products of imidazoles-derivatives.
Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem