Gortinskaya, T. V. published the artcileSome derivatives of 4,4′-dihydrazinodiphenyl sulfone and 4-hydrazinophenyl 2-acetamido-5-thiazolyl sulfone, SDS of cas: 45533-87-7, the publication is Zhurnal Obshchei Khimii (1957), 1960-4, database is CAplus.
Heating 1.4 g. opianic acid in 50 ml. EtOH with 1 g. (p-HCl.H2NNHC6H4)2SO2 in 10 ml. H2O gave a precipitate of 2.2 g. {4-[2,3,4-HO2C(MeO)2C6H2CH:NNH]C6H4}2SO2 (I), m. 268-9°. If the reaction is run in H2O there is formed yellow II, m. 258-60°, which changes to I on heating with ROH or alc. H2SO4. Hydrogenation of 4-nitrophenyl-2-amino-5-thiazolyl sulfone in EtOH over Raney Ni gave 87% 4-H2NC6H4 analog, m. 217-19°. Hydrogenation of 4-nitrophenyl-2-acetamido-5-thiazolyl sulfone over Raney Ni in H2O gave the 4-H2NC6H4 analog, m. 268-9°. This (5.4 g.), 42 ml. AcOH, 21 ml. concentrated HCl, and 10.5 ml. H2O diazotized with 1.1 g. NaNO2 at 0° and the solution treated with 7.85 g. SnCl2 in 38.5 ml. HCl, and kept 2 days at room temperature gave 0.3 g. p-H2NNHC6H4 analog HCl salt, m. 222°; the filtrate treated with H2S and filtered gave with NH4OH 1.6 g. free base (IIA), m. 243-5°. The following hydrazones are reported: from (p-H2NNHC6H4)2SO2 (III) and p-HOC6H4CHO, m. 238-40°; from III and p-AcNHC6H4CHO, m. 262-5°; from III and 3,4-MeO(HO)C6H3CHO, m. 250-2°; from 4-hydrazinophenyl-2-acetamido-5-thiazolyl sulfone (IV) and p-AcNHC6H4CHO, m. 221-3°; from IV and 3,4-MeO(HO)C6H3CHO, m. 238-40°; from IV and opianic acid, m. 263-4°. III showed some in vitro activity against human and avian tuberculosis and acid-fast saprophytic sp., Microsporon sp., Trichophyton sp., Achorion sp., and actinomyces sp. Some activity was found for III hydrazone, p-HOC6H4CHO, and IIA.
Zhurnal Obshchei Khimii published new progress about 45533-87-7. 45533-87-7 belongs to imidazoles-derivatives, auxiliary class Imidazole,Alcohol,Imidazole, name is (2-Methyl-1H-imidazol-4-yl)methanol, and the molecular formula is C5H8N2O, SDS of cas: 45533-87-7.
Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem