El Alaoui, Abdessamad published the artcileShiga toxin-mediated retrograde delivery of a topoisomerase I inhibitor prodrug, Safety of N-(4-Hydroxyphenyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, the publication is Angewandte Chemie, International Edition (2007), 46(34), 6469-6472, database is CAplus and MEDLINE.
A retrograde strategy: An innovative cancer-cell delivery concept exploits the naturally evolved characteristics of the Shiga toxin B-subunit (STxB) for the intracellular activation of a newly synthesized prodrug at the level of the biosynthetic/secretory pathway. Retrograde prodrug targeting allows its slow release, which should sustain the presence of the active principle in dividing tumor cells.
Angewandte Chemie, International Edition published new progress about 901770-40-9. 901770-40-9 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Amide, name is N-(4-Hydroxyphenyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C16H21N3O3S, Safety of N-(4-Hydroxyphenyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide.
Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem