Alasmary, Fatmah A. S. published the artcileSynthesis and evaluation of selected benzimidazole derivatives as potential antimicrobial agents, Quality Control of 7467-35-8, the publication is Molecules (2015), 20(8), 15206-15223, database is CAplus and MEDLINE.
A library of 53 benzimidazole derivatives, with substituents at positions 1, 2 and 5, were synthesized and screened against a series of reference strains of bacteria and fungi of medical relevance. The SAR analyses of the most promising results showed that the antimicrobial activity of the compounds depended on the substituents attached to the bicyclic heterocycle. In particular, some compounds displayed antibacterial activity against two methicillin-resistant Staphylococcus aureus (MRSA) strains with min. inhibitory concentrations (MICs) comparable to the widely-used drug ciprofloxacin. The compounds had some common features; three possess 5-halo substituents; two were derivatives of (S)-2-ethanaminebenzimidazole; and the others were derivatives of one 2-(chloromethyl)-1H-benzo[d]imidazole and (1H-benzo[d]imidazol-2-yl)methanethiol. The results from the antifungal screening were also very interesting: 23 compounds exhibited potent fungicidal activity against the selected fungal strains. They displayed equivalent or greater potency in their MIC values than amphotericin B. The 5-halobenzimidazole derivatives were considered as promising broad-spectrum antimicrobial candidates that deserve further study for potential therapeutic applications.
Molecules published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C9H10N2O, Quality Control of 7467-35-8.
Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem