Month: November 2022

Bevilacqua, Valentina published the artcileCopper-Chelating Azides for Efficient Click Conjugation Reactions in Complex Media, Related Products of imidazoles-derivatives, the publication is Angewandte Chemie, International Edition (2014), 53(23), 5872-5876, database is CAplus and MEDLINE.

The concept of chelation-assisted copper catalysis was employed for the development of new azides that display unprecedented reactivity in the copper(I)-catalyzed azide-alkyne [3+2] cycloaddition (CuAAC) reaction. Azides that bear strong copper-chelating moieties were synthesized; these functional groups allow the formation of azide copper complexes that react almost instantaneously with alkynes under diluted conditions. Efficient ligation occurred at low concentration and in complex media with only one equivalent of copper, which improves the biocompatibility of the CuAAC reaction. Furthermore, such a click reaction allowed the localization of a bioactive compound inside living cells by fluorescence measurements.

Angewandte Chemie, International Edition published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C9H10N2O, Related Products of imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Balaban, I. E. published the artcileTrypanocidal action and chemical constitution. III. Arsonic acids containing the glyoxaline nucleus, Safety of 4-(1H-Imidazol-2-yl)aniline, the publication is Journal of the Chemical Society, Abstracts (1925), 2801-14, database is CAplus.

Glyoxaline-4(or 5)-carboxyanilide nitrate is dimorphous, both forms crystallizing with 0.5 H₂O, unstable fluffy needles and stable, stout prisms, m. 170-1° (decomposition); gradually added to concentrated H₂SO₄ at O°, there results 36 g. of the p-nitro derivative (I), crystallizing with 2 AcOH, m. 307° (corrected), soluble in 2 N NaOH with a pale yellow color (HCl salt, crystallizing with 1 H₂O, decomposes about 298°; nitrate, m. 205° (decomposition)) and 14.3% of the o-nitro derivative, bright yellow, m. 229° (HCl salt, yellow prisms; nitrate, yellow, m. 196° (decomposition)). Reduction of I with SnCl₂ and HCl gives the p-amino derivative (II), plates, m. 228°; di-HCl salt, crystallizing with 1 H₂O, blackens about 290°; the diazo solution couples with alk. β-C₁₀H₇OH with a red color; chlorostannate, pale yellow, m. 290° (decomposition); picrate, yellow, darkens 256°, decomposes 266°, crystallizing with 1.5 H₂O. The o-amino derivative (III), m. 270°; di-HCl salt, crystallizing with 0.5 H₂O, decomposes 310°; diazoimide, m. 195-6°, produces no color with alk. β-C₁₀H₇OH; it is very sparingly soluble in H₂O and will detect HNO₂ as a solid crystalline derivative at a dilution of 1 in 6400 in the presence of AcONa, or, conversely, the anilide can be detected at a dilution of 1 in 5000. Dipicrate, crystallizing with 2.5 H₂O, m. 242° (decomposition). II, diazotized and treated with As₂O₃, gives 36% of glyoxaline-4′(or 5′)-carboxy-p-aminophenylarsonic acid, pale yellow, darkens 280°, crystallizing from 25% HCO₂H with 1 H₂O; Mg salt, fine needles; Ca salt, anisotropic spheroids; Na salt, needles; HCl salt, fine needles. Nitration at 0° gives the 3-nitro derivative, yellow plates with 1 H₂O, m. about 327° (decomposition); Mg, Ca, Ba and Li salts. Reduction with FeCl₂ in NaOH at -5° gives 86% of the 3-amino derivative, prisms, does not m. 320°; it crystallines with 0.5 H₂O, not lost at 100°. NaNO₂ in a HCl solution causes the immediate precipitation of the diazoimide, micro-leaflets, which does not couple with β-C₁₀H₇OH; Mg and Ca salts. 2-p-Aminophenylglyoxaline, oil turns brown on exposure to the air; di-HCl salt, prisms, darkens about 300°; chlorostannate, needles; picrate, orange, decomposes about 239°; no arsonic acid could be prepared from this compound 2-p-Nitrophenyl-1-methylglyoxaline, pale yellow, m. 116.5° (corrected); HCl salt, elongated plates; chloroaurate, Au-yellow, decomposes 226° (corrected), solubility 1 part in 300 boiling 3 N HCl; nitrate, plates, effervescing 186° (corrected); picrate, m. 212° (corrected). 2-m-Aminophenylglyoxaline, m. 203-4°; the monohydrate partly m. 130-40° and finally 202-3°; di-HCl salt, crystallines with 1 H₂O, m. 282° (decomposition); chlorostannate, prisms; picrate, decomposes 218°. No arsonic acid could be obtained. 2-0-Aminophenylglyoxaline, m. 136-7°; di-HCl salt, m. 234-6°, decomposes slightly higher; chlorostannate, thin plates; NaNO₂ gives a triazine, m. 113-4°, whose HCl salt crystallines in needles; it does not couple with alk. β-C₁₀H₇OH; picrate, m. 211-2°. 4-p-Amino-phenylglyoxaline, m. 98° (corrected); di-HCl salt, darkens 310°; chlorostannate, darkens 310°; dipicrate, yellow, m. 240° (decomposition); the diazo solution gives an intense purple dye with alk. β-C₁₀H₇OH; but a similar color is obtained with NaOH alone. Pauly’s reagent gives an intense red color. Glyoxaline-4(or 5)-phenyl-p-arsonic acid, reddish yellow, does not m. 310°; the yield is very small. 4-o-Aminophenylglyoxaline, m. 131°; di-HCl salt, crystallines with 1 H₂O, which is not lost at 95°, effervesce 256°; NaNO₂ gives a bright yellow solution, from which the triazine seps.; it is insoluble in alkali and does not couple with alk. βC₁₀H₇OH. Dipicrate, decomposes about 200°; normal tartrate, crystallizing with 1.5 H₂O and losing 1 H₂O in vacuum over H₂SO₄, m. 95-7°, effervesces about 130°; α₅₄₆₁ 14.8° (c 0.914 in H₂O); di-d-camphor-10-sulfonate, m. 198-200°, α₅₁₅₁ 21.3° (c 1.0 in H₂O). In the action of 28 cc. Me₂SO₄ on 40 g. 2-phenylglyoxaline, there were obtained 32% unchanged product, 18.2% 2-phenyl-1-methylglyoxaline, pale yellow oil, b₁₅ 175° (HCl salt, with 2 H₂O; chloroaurate, deep yellow, m. 189° (corrected); nitrate, m. about 100°; picrate, m. 133° (corrected); H oxalate, m. 135° (corrected)) and, after evaporation of the aqueous solution with HCl, 26.7% of the methochloride, hygroscopic, m. 272° (chloroaurate, pale yellow, m. 134° (corrected)). Distillation of the methochloride gave 56% of 2-phenyl-1-methylglyoxaline. The therapeutic action of some of these compounds is given.

Journal of the Chemical Society, Abstracts published new progress about 13682-33-2. 13682-33-2 belongs to imidazoles-derivatives, auxiliary class Imidazole,Amine,Benzene, name is 4-(1H-Imidazol-2-yl)aniline, and the molecular formula is C9H9N3, Safety of 4-(1H-Imidazol-2-yl)aniline.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Han, Gyeongyeop published the artcileProtein-patterning on functionalized, non-biofouling poly[N-acryloxysuccinimide-co-oligo(ethylene glycol) methyl ether methacrylate] film-coated PET surfaces, Related Products of imidazoles-derivatives, the publication is Macromolecular Research (2018), 26(3), 263-269, database is CAplus.

We successfully fabricated poly(ethylene terephthalate) (PET) surfaces through a perfluoroaryl azide-based photochem. reaction, and subsequently formed an intrinsically activated, non-biofouling poly[N-acryloxysuccinimide-co-oligo(ethylene glycol) Me ether methacrylate] on the surface through surface-initiated, controlled radical polymerization The grafted copolymer film on PET facilely generated a protein pattern using a microcontact printing technique without employing both an activation step to introduce an active functional group (e.g., succinimidyl ester) and a passivation process for minimizing non-specific adsorption. Consequently, we characterized the functionalized PET surfaces by using various methods including contact angle measurement, XPS, scanning probe microscopy (SPM), field-emission SEM (FE-SEM). In addition, we evaluated the non-biofouling efficacy of the protein-patterned copolymer film on PET by confocal laser scanning microscopy.[Figure not available: see fulltext.].

Macromolecular Research published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Related Products of imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Yu, Hye-Weon published the artcileMultiplex competitive microbead-based flow cytometric immunoassay using quantum dot fluorescent labels, Quality Control of 359860-27-8, the publication is Analytica Chimica Acta (2012), 191-198, database is CAplus and MEDLINE.

The simultaneous anal. of environmental hazards, microcarrier-based multiplex technologies show great promise. Further integration with biofunctionalized quantum dots (QDs) creates new opportunities to extend the capabilities of multicolor flow cytometry with their unique fluorescence properties. We developed a competitive microbead-based flow cytometric immunoassay using QDs fluorescent labels for simultaneous detection of 2 analytes, bringing the benefits of sensitive, rapid and easy-of-manipulation anal. tool for environmental contaminants. As model target compounds, the cyanobacterial toxin microcystin-LR and the polycyclic aromatic hydrocarbon compound benzo[a]pyrene were selected. The assay was carried out in 2 steps: the competitive immunol. reaction of multiple targets using their exclusive sensing elements of QD/antibody detection probes and antigen-coated microsphere, and the subsequent flow cytometric anal. The fluorescence of the QD-encoded microsphere was thus found to be inversely proportional to target analyte concentration Under optimized conditions, the proposed assay performed well within 30 min for the identification and quant. anal. of the 2 contaminants. For microcystin-LR and benzo[a]pyrene, dose-response curves with IC₅₀ values of 5 and 1.1 μg/L and dynamic ranges of 0.52-30 and 0.13-10 μg/L were obtained, resp. Recovery was 92.6-106.5% for 5 types of water samples (bottled water, tap water, surface water and seawater) using only filtration as sample pretreatment.

Analytica Chimica Acta published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C13H9FO, Quality Control of 359860-27-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Lee, Bong Soo published the artcileFormation of activation-free, selectively bioconjugatable poly(N-acryloxysuccinimide-co-oligoethylene glycol methyl ether methacrylate) films by surface-initiated ARGET ATRP, Recommanded Product: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, the publication is Journal of Polymer Science, Part A: Polymer Chemistry (2017), 55(2), 329-337, database is CAplus.

Activation-free copolymeric films possessing high selectivity to target proteins and low biofouling background are prepared via controlled radical polymerization The copolymeric films are generated by surface-initiated activators regenerated by electron transfer atom transfer radical polymerization (SI-ARGET ATRP) of N-acryloxysuccinimide (NAS) and oligo(ethylene glycol) Me ether methacrylate (OEGMEMA) by controlling the molar feed ratio of the two monomers. The formation of copolymeric films is characterized by ellipsometry, contact angle goniometry, FTIR spectroscopy, and XPS. The prepared copolymeric films are biotinylated without an activation step. Biotin-streptavidin association is employed as a model system to investigate both selective binding and the relevant signal-to-noise (S/N) ratio. When the molar feed ratio of NAS and OEGMEMA is 2:8, the copolymeric film is optimized to give the highest S/N ratio (339.8) according to surface plasmon resonance studies. The highly selective bioconjugation is used to generate micropatterns of rhodamine-conjugated streptavidin on the copolymeric film. © 2016 Wiley Periodicals, Inc.J. Polym. Sci., Part A: Polym.Chem. 2016.

Journal of Polymer Science, Part A: Polymer Chemistry published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Recommanded Product: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Cao, Lei published the artcileRapid Continuous-Flow Water-Free Synthesis of Ultrapure Ionic Liquids Assisted by Microwaves, Formula: C8H15ClN2, the publication is Organic Process Research & Development (2022), 26(1), 207-214, database is CAplus.

A wide range of imidazole, pyridine including insoluble polymers, and tertiary amine derivatives rapidly reacted with orthoformate using various Bronsted acids or ammonium salts to control the anionic parts. The corresponding ionic liquids were formed in excellent yields under microwave-batch conditions within 10 min. A scale-up synthesis was easily achieved using a microwave flow system. Typically, [BMIM][BF₄] was produced at a rate of 26.2 g/h under an Ar atm. with an E-factor of 0.8. Both batch and flow experiments were also performed in a domestic microwave oven.

Organic Process Research & Development published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, Formula: C8H15ClN2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Lee, Hyeri published the artcileAnalysis of Cyazofamid and its Metabolite in the Environmental and Crop Samples Using LC-MS/MS, SDS of cas: 120118-14-1, the publication is Bulletin of Environmental Contamination and Toxicology (2014), 93(5), 586-590, database is CAplus and MEDLINE.

A rapid and robust LC-MS/MS method for the anal. of cyazofamid and its metabolite, 4-chloro-5-p-tolylimidazole-2-carbonitrile (CCIM), in environmental samples (soil and water) and a variety of crops (apple, mandarin, Kimchi cabbage, green pepper, potato and soybean) was established in this study. Those compounds were analyzed by selected reaction monitoring with electrospray ionization (pos. mode) on LC-MS/MS. Method limit of quantitations were 2 ng g^-1 (cyazofamid) and 5 ng g^-1 (CCIM) for soil/crop samples, while 0.02 ng mL^-1 (cyazofamid) and 0.05 ng mL^-1 (CCIM) were achieved for water samples. Matrix effect (%) was different depending on sample matrixes. For recovery tests, soil/crop samples were treated with QuEChERS method and water samples were extracted with dichloromethane. The recoveries of target analytes in the environmental and crop samples were 80.2%-105.1% for cyazofamid and 75.1%-99.1% for CCIM (coefficients of variation; ≤16.4%).

Bulletin of Environmental Contamination and Toxicology published new progress about 120118-14-1. 120118-14-1 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Nitrile,Benzene, name is 4-Chloro-5-(p-tolyl)-1H-imidazole-2-carbonitrile, and the molecular formula is C11H8ClN3, SDS of cas: 120118-14-1.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Jeong, Jae Hyun published the artcileA novel immobilization technique using a poly(amino acid) multilayer designed for surface plasmon resonance sensing, HPLC of Formula: 359860-27-8, the publication is Chemical Physics Letters (2006), 421(4-6), 373-377, database is CAplus.

The novel immobilization technique using a poly(amino acid) multilayer was designed for the SPR sensing platform. The poly(amino acid) multilayer was confirmed as a relatively hydrophilic surface with little tendency for nonspecific adsorption of biomols. and a flat surface that the biomol. interactions can occur uniformly on the sensing surface. The poly(amino acid) multilayer functionalized with biotin was investigated to control the surface d. and to estimate the optimum space between ligands for effective SPR sensing. This multilayer study demonstrates the importance of surface d. which is significantly sensitive for fabrication of surface functional group in the monitoring of kinetic phenomena.

Chemical Physics Letters published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, HPLC of Formula: 359860-27-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Akkahat, Piyaporn published the artcileDevelopment of a Novel Antifouling Platform for Biosensing Probe Immobilization from Methacryloyloxyethyl Phosphorylcholine-Containing Copolymer Brushes, Name: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, the publication is Langmuir (2012), 28(13), 5872-5881, database is CAplus and MEDLINE.

The immobilization of thiol-terminated poly[(methacrylic acid)-ran-(2-methacryloyloxyethyl phosphorylcholine)] (PMAMPC-SH) brushes on gold-coated surface plasmon resonance (SPR) chips was performed using the grafting to approach via self-assembly formation. The copolymer brushes provide both functionalizability and antifouling characteristics, desirable features mandatorily required for the development of an effective platform for probe immobilization in biosensing applications. The carboxyl groups from the methacrylic acid (MA) units were employed for attaching active biomols. that can act as sensing probes for biospecific detection of target mols., whereas the 2-methacryloyloxyethyl phosphorylcholine (MPC) units were introduced to suppress unwanted nonspecific adsorption. The detection efficiency of the biotin-immobilized PMAMPC brushes with the target mol., avidin (AVD), was evaluated in blood plasma in comparison with the conventional 2D monolayer of 11-mercaptoundecanoic acid (MUA) and homopolymer brushes of poly(methacrylic acid) (PMA) also immobilized with biotin using the SPR technique. Copolymer brushes with 79 mol % MPC composition and a mol. weight of 49.3 kDa yielded the platform for probe immobilization with the best performance considering its high S/N ratio as compared with platforms based on MUA and PMA brushes. In addition, the detection limit for detecting AVD in blood plasma solution is 1.5 nM (equivalent to 100 ng/mL). The results demonstrated the potential for using these newly developed surface-attached PMAMPC brushes for probe immobilization and subsequent detection of designated target mols. in complex matrixes such as blood plasma and clin. samples.

Langmuir published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Name: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Nambo, Masakazu published the artcileDevelopment of Versatile Sulfone Electrophiles for Suzuki-Miyaura Cross-Coupling Reactions, Recommanded Product: 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, the publication is ACS Catalysis (2017), 7(2), 1108-1112, database is CAplus.

The development of fluorinated sulfone derivatives as versatile electrophiles for Suzuki-Miyaura cross-coupling reactions is described. Introducing electron-withdrawing groups on the aryl ring of the sulfone facilitates the Pd-catalyzed activation of the C-SO₂ bonds. Cross-coupling reactions with fluorinated sulfone electrophiles are reported, leading to a variety of multiply arylated products in good yields. The reactivity of this unusual electrophile is benchmarked vs. common electrophiles and its use in iterative cross-couplings for concise synthesis of biol. active mols. is described.

ACS Catalysis published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, Recommanded Product: 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem