Month: November 2022

Sanghavi, N. M. published the artcileColorimetric determination of insoluble phosphomolybdic acid complexes of antihistamines, Safety of N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, the publication is Indian Drugs (1980), 18(1), 25-8, database is CAplus.

Antihistamines viz. antazoeine-HCl [2508-72-7], dimenhydrinate [523-87-5], cyclizine-HCl [303-25-3], chlorcyclizine-HCl [14362-31-3] and diphenhydramine-HCl [147-24-0] are precipitated with phosphomolybdic acid; hydrazine hydrate quant. reduces the insoluble complexes to molybdenum blue which is measured colorimetrically. A linear relationship exists between the absorbance of the reaction product and the concentration of the drug present. Recovery from spiked tablet samples is 99.0-100.3%.

Indian Drugs published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Safety of N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Barnhill, Hannah N. published the artcileDual modification of turnip yellow mosaic virus: synthesis of a biotinylated luminescent nanoparticle, Quality Control of 359860-27-8, the publication is PMSE Preprints (2006), 379-380, database is CAplus.

In this study, turnip yellow mosaic virus (TYMV) was employed as a scaffold for creating a bi-functional nanoparticle. TYMV is a 30 nm icosohedral virus with 60 asym. units and 180 protein subunits. As a proof concept that TYMV can be used as a multifunctional nanoparticle, luminescent metal complexes and the bio-active mol. biotin was conjugated onto the surface of TYMV using traditional bioconjugation methods. This study showed that the particle retains its integrity after the reaction and is stable to the attached functional groups. In addition, the two functional groups still retain their properties and can interact with each other on the surface as demonstrated by fluorescence resonance energy transfer.

PMSE Preprints published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Quality Control of 359860-27-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Borcard, Francoise published the artcileSurface modification of biomaterials for conjugation with human fetal osteoblasts, Recommanded Product: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, the publication is Chimia (2013), 67(4), 213-217, database is CAplus and MEDLINE.

Surface functionalization of hydroxyapatite (HA) and β-tricalcium phosphate (TCP) bioceramics with chem. ligands containing a pyrrogallol moiety was developed to improve the adhesion of bone cell precursors to the biomaterials. Fast and biocompatible copper-free click reaction with azido-modified human fetal osteoblasts resulted in improved cell binding to both HA and TCP bioceramics, opening the way for using this methodol. in the preparation of cell-engineered bone implants.

Chimia published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Recommanded Product: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Zhi, Hui published the artcileOccurrence and spatiotemporal dynamics of pharmaceuticals in a temperate-region wastewater effluent-dominated stream: variable inputs and differential attenuation yield evolving complex exposure mixtures, Recommanded Product: Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, the publication is Environmental Science & Technology (2020), 54(20), 12967-12978, database is CAplus and MEDLINE.

Effluent-dominated streams are becoming increasingly common in temperate regions and generate complex pharmaceutical mixture exposure conditions that may impact aquatic organisms via drug-drug interactions. Here, we quantified spatiotemporal pharmaceutical exposure concentrations and composition mixture dynamics during baseflow conditions at four sites in a temperate-region effluent-dominated stream (upstream, at, and progressively downstream from effluent discharge). Samples were analyzed monthly for 1 yr for 109 pharmaceuticals/degradates using a comprehensive U.S. Geol. Survey anal. method and biweekly for 2 years focused on 14 most common pharmaceuticals/degradates. We observed a strong chem. gradient with pharmaceuticals only sporadically detected upstream from the effluent. Seventy-four individual pharmaceuticals/degradates were detected, spanning 5 orders of magnitude from 0.28 to 13 500 ng/L, with 38 compounds detected in >50% of samples. “Biweekly” compounds represented 77 ± 8% of the overall pharmaceutical concentration The antidiabetic drug metformin consistently had the highest concentration with limited instream attenuation. The antihistamine drug fexofenadine inputs were greater during warm- than cool-season conditions but also attenuated faster. Differential attenuation of individual pharmaceuticals (i.e., high = citalopram; low = metformin) contributed to complex mixture evolution along the stream reach. This research demonstrates that variable inputs over multiple years and differential instream attenuation of individual compounds generate evolving complex mixture exposure conditions for biota, with implications for interactive effects.

Environmental Science & Technology published new progress about 161796-78-7. 161796-78-7 belongs to imidazoles-derivatives, auxiliary class Membrane Transporter/Ion Channel,Proton Pump, name is Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, and the molecular formula is C7H6Cl2O, Recommanded Product: Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Zhukhovitskiy, Aleksandr V. published the artcileMigratory Insertion of Carbenes into Au(III)-C Bonds, Safety of 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, the publication is Journal of the American Chemical Society (2018), 140(1), 466-474, database is CAplus and MEDLINE.

Migratory insertion of carbon-based species into transition-metal-carbon bonds is a mechanistic manifold of vast significance: it underlies the Fischer-Tropsch process, Mizoroki-Heck reaction, Ziegler-Natta and analogous late-transition-metal-catalyzed olefin polymerizations, and a number of carbonylative methods for the synthesis of ketones and esters, among others. Although this type of reactivity is well-precedented for most transition metals, gold constitutes a notable exception, with virtually no well-characterized examples known to date. Yet, the complementary reactivity of gold to numerous other transition metals would offer new synthetic opportunities for migratory insertion of carbon-based species into gold-carbon bonds. Here we report the discovery of well-defined Au(III) complexes that participate in rapid migratory insertion of carbenes derived from silyl- or carbonyl-stabilized diazoalkanes into Au-C bonds at temperatures ≥ -40 °C. Through a combined theor. and exptl. approach, key kinetic, thermodn., and structural details of this reaction manifold were elucidated. This study paves the way for homogeneous gold-catalyzed processes incorporating carbene migratory insertion steps.

Journal of the American Chemical Society published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C17H14N2O2, Safety of 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Wessels, Alina published the artcileFormation of Breslow Intermediates from N-Heterocyclic Carbenes and Aldehydes Involves Autocatalysis by the Breslow Intermediate, and a Hemiacetal, HPLC of Formula: 258278-25-0, the publication is Angewandte Chemie, International Edition (2022), 61(23), e202117682, database is CAplus and MEDLINE.

Under aprotic conditions, the stoichiometric reaction of N-heterocyclic carbenes (NHCs) such as imidazolidin-2-ylidenes with aldehydes affords Breslow Intermediates (BIs), involving a formal 1,2-C-to-O proton shift. We herein report kinetic studies (NMR), complemented by DFT calculations, on the mechanism of this kinetically disfavored H-translocation. Variable time normalization anal. (VTNA) revealed that the kinetic orders of the reactants vary for different NHC-to-aldehyde ratios, indicating different and ratio-dependent mechanistic regimes. We propose that for high NHC-to-aldehyde ratios, the H-shift takes place in the primary, zwitterionic NHC-aldehyde adduct. With excess aldehyde, the zwitterion is in equilibrium with a hemiacetal, in which the H-shift occurs. In both regimes, the critical H-shift is auto-catalyzed by the BI. Kinetic isotope effects observed for R-CDO are in line with our proposal. Furthermore, we detected an H-bonded complex of the BI with excess NHC (NMR).

Angewandte Chemie, International Edition published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C8H11NO, HPLC of Formula: 258278-25-0.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Harsagi, Nikoletta published the artcileSynthesis of Cyclic Phosphinates by Microwave-Assisted Ionic-Liquid-Promoted Alcoholysis, SDS of cas: 79917-90-1, the publication is Synthesis (2022), 54(17), 3899-3905, database is CAplus.

1-Alkoxy-3-methyl- and 3,4-dimethyl-3-phospholene 1-oxides, as well as 1-alkoxy-3-methylphospholane 1-oxides were prepared in good yields by the microwave (MW)-assisted [bmim][PF ₆]-catalyzed transesterification of the corresponding Me or Et esters. The alcoholyzes studied represent another case, where MW irradiation has had a crucial role on the reaction. The method developed is an alternative possibility to other esterifications starting from the corresponding phosphinic chlorides and acids.

Synthesis published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, SDS of cas: 79917-90-1.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Bezzubov, Stanislav I. published the artcileIridium(III) 2-Phenylbenzimidazole Complexes: Synthesis, Structure, Optical Properties, and Applications in Dye-Sensitized Solar Cells, Name: 1,2-Diphenyl-1H-benzo[d]imidazole, the publication is European Journal of Inorganic Chemistry (2016), 2016(3), 347-354, database is CAplus.

Bis-cyclometalated Ir(III) complexes, [Ir(LH)₂(H₂dcbpy)][PF₆] (1), [Ir(LMe)₂(H₂dcbpy)][PF₆] (2), and [Ir(LPh)₂(H₂dcbpy)][PF₆] (3), where LH = 1-H-2-phenylbenzimidazole, LMe = 1-methyl-2-phenylbenzimidazole, LPh = 1,2-diphenylbenzimidazole, and H₂dcbpy = 2,2′-bipyridine-4,4′-dicarboxylic acid, was synthesized and fully characterized by elemental anal., ¹H and ³¹P NMR spectroscopy, mass spectrometry, and single-crystal x-ray anal. The complexes show strong luminescence in the yellow-orange region in EtOH at room temperature (quantum yield is up to 22 %), and absorb light up to 550 nm with molar absorptivities of 1500-2000 M^-1 cm^-1. Complexes 1 and 2 possess very similar optical properties, whereas the introduction of the Ph ring (complex 3) causes a hypsochromic shift (≈ 30 nm) of the luminescent maximum as well as resulting in an almost 50% increase in the extinction coefficient at 490 nm compared with 1 and 2. A dye-sensitized solar cell (DSSC) based on complex 3 exhibits a short-circuit photocurrent of 2.8 mA cm^-2, an open-circuit photovoltage of 0.44 V, and a power conversion efficiency of 0.7%.

European Journal of Inorganic Chemistry published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C19H14N2, Name: 1,2-Diphenyl-1H-benzo[d]imidazole.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Bano, Kulsum published the artcileFacile Synthesis of Benzimidazole and Benzothiazole Compounds Mediated by a Zinc Precatalyst Supported by an Iminopyrrole-Morpholine Ligand, Name: 1,2-Diphenyl-1H-benzo[d]imidazole, the publication is European Journal of Inorganic Chemistry (2022), 2022(10), e202200023, database is CAplus.

Three zinc complexes, with the general formula {κ2-C₄H₃NH[2-CH=NCH₂CH₂N(CH₂CH₂)₂O]ZnX₂} [X = Cl, Br, I], supported by a neutral iminopyrrole-morpholine ligand, were synthesized by the reaction between {C₄H₃NH-2-[CH=NCH₂CH₂N (CH₂CH₂)₂O]} and anhydrous zinc dihalides (ZnCl₂, ZnBr₂, ZnI₂) at ambient temperature in dry methanol. The zinc complexes were fully characterized using multinuclear NMR spectroscopic techniques and the mol. structures of complexes in their solid states were determined by single-crystal X-ray diffraction anal. The zinc diiodo complex proved to be a competent precatalyst in the formation of a wide range of benzimidazole and benzothiazole compounds, via aerobic oxidative condensation of several benzylamines with o-phenylenediamine, N-phenyl-o-phenylene-diamine, and o-mercaptoaniline. The benzimidazole and benzothiazole derivatives were successfully characterized using ¹H and ¹³C{1H} NMR spectroscopy.

European Journal of Inorganic Chemistry published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C19H14N2, Name: 1,2-Diphenyl-1H-benzo[d]imidazole.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Kayarohanam, Saminathan published the artcileA validated RP HPLC method for the estimation of esomeprazole sodium injection, Product Details of C17H18N3NaO3S, the publication is International Journal of Pharmacy (Hyderabad, India) (2014), 4(2), 183-188, database is CAplus.

Esomeprazole is chem. bis (5methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl) methyl]sulfinyl]- 1Hbenzimidazole-1-yl). It is a gastric proton-pump inhibitor (PPI) used in treatment of gastric-acid related diseases. A Simple, sensitive, selective and accurate reverse phase high performance liquid chromatog. (RP-HPLC) methods were developed, estimated and validated for the anal. of Esomeprazole sodium in bulk and injection forms. The chromatog. separation was performed by the using C8, column having 250 × 4.6mm 5μm. Using mobile phase containing Acetonitrile and phosphate buffer (58:42vol./volume) adjusted to PH 7.6 with phosphoric acid. The anal. was run at a flow rate of 1.5ml/min and injection volume was 20 μL. The detection was monitored at 280nm. The retention time of Esomeprazole was 2.93 min. The developed method was validated for precision, intermediate precision (ruggedness), linearity, specificity, accuracy, and stability. Recovery of Esomeprazole in formulations was found to be in the range of 99.08%, 100.86%, and 101.52% resp. And the correlation coefficient was 0.999. Hence, it was concluded that the developed method is suitable for routine anal. due to its less anal. time.

International Journal of Pharmacy (Hyderabad, India) published new progress about 161796-78-7. 161796-78-7 belongs to imidazoles-derivatives, auxiliary class Membrane Transporter/Ion Channel,Proton Pump, name is Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, and the molecular formula is C17H18N3NaO3S, Product Details of C17H18N3NaO3S.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem