Month: November 2022

On August 11, 2020, Li, Yongfei; Chen, Mie; Yao, Bowen; Lu, Xun; Song, Boyang; Vasilatos, Shauna N.; Zhang, Xiang; Ren, Xiaomei; Yao, Chang; Bian, Weihe; Sun, Lizhu published an article.Electric Literature of 5036-48-6 The title of the article was Dual pH/ROS-Responsive Nanoplatform with Deep Tumor Penetration and Self-Amplified Drug Release for Enhancing Tumor Chemotherapeutic Efficacy. And the article contained the following:

Poor deep tumor penetration and incomplete intracellular drug release remain challenges for antitumor nanomedicine application in clin. settings. Herein, a nanomedicine (RLPA-NPs) is developed that can achieve prolonged blood circulation, deep tumor penetration, active-targeting of cancer cells, endosome/lysosome escape, and intracellular selectivity self-amplified drug release for effective drug delivery. The RLPA-NPs are constructed by encapsulation of a pH-sensitive polymer octadecylamine-poly(aspartate-1-(3-aminopropyl) imidazole) (OA-P(Asp-API)) and a ROS-generation agent, β-Lapachone (Lap), in micelles assembled by the tumor-penetration peptide internalizing RGD (iRGD)-modified ROS-responsive paclitaxel (PTX)-prodrug. iRGD could promote RLPA-NPs penetration into deep tumor tissue, and specific targeting to cancer cells. After internalization by cancer cells through receptor-mediated endocytosis, OA-P(Asp-API) can rapidly protonate in the endosome’s acidic environment, resulting in RLPA-NPs escape from the endosome through the “proton sponge effect”. At the same time, the RLPA-NPs micelle disassembles, releasing Lap and PTX-prodrug. Subsequently, the released Lap could generate ROS, consequently amplifying and accelerating PTX release to kill tumor cells. The in vitro and in vivo studies demonstrated that RLPA-NPs can significantly improve the therapeutic effect compared to control groups. Therefore, RLPA-NPs are a promising nanoplatform for overcoming multiple physiol. and pathol. barriers to enhance drug delivery. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Electric Literature of 5036-48-6

The Article related to ph ros responsive nanoparticle micelle antitumor paclitaxel prodrug uptake, deep tumor penetration, lysosome escape, ph/ros-cascade responsive, proton sponge effect, self-amplified drug release and other aspects.Electric Literature of 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On April 15, 2020, Suo, Hongbo; Xu, Lili; Xue, Yu; Qiu, Xiang; Huang, He; Hu, Yi published an article.SDS of cas: 5036-48-6 The title of the article was Ionic liquids-modified cellulose coated magnetic nanoparticles for enzyme immobilization: Improvement of catalytic performance. And the article contained the following:

In this work, ionic liquids-modified magnetic CM-cellulose nanoparticles (IL-MCMC) were prepared and used as supports for enzyme immobilization. The specific activity of immobilized lipase PPL-IL-MCMC was 1.43 and 2.81 folds higher than that of free PPL and PPL-MCMC, resp. Water contact angle anal. indicated that the introduction of ionic liquids increased the hydrophobicity of supports, which in tune induced the lid-opening of lipase, allowing its active sites to become more accessible. In addition, the affinity between lipase and substrate immobilized on the prepared supports was enhanced. The same method was also applied to analyze immobilize penicillin G acylase (PGA) to further investigate the general applicability of the method. The results showed that the immobilized PGA exhibited higher stability than many other reported PGAs. The developed composites may be utilized as excellent supports for enzyme immobilization in industrial application. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).SDS of cas: 5036-48-6

The Article related to ionic liquid modified cellulose coated magnetic nanoparticle enzyme immobilization, covalent immobilization, enzymatic performance, hydrophobicity, ionic liquids, magnetic cellulose nanoparticles and other aspects.SDS of cas: 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On January 15, 2014, Boix, C.; Ibanez, M.; Zamora, T.; Sancho, J. V.; Niessen, W. M. A.; Hernandez, F. published an article.Recommanded Product: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole The title of the article was Identification of new omeprazole metabolites in wastewaters and surface waters. And the article contained the following:

Omeprazole is 1 of the world-wide most consumed pharmaceuticals for treatment of gastric diseases. As opposed to other frequently used pharmaceuticals, omeprazole is scarcely detected in urban wastewaters and environmental waters. This was corroborated in a previous research, where parent omeprazole was not detected while 4 transformation products (TPs), mainly resulting from hydrolysis, were found in effluent wastewaters and surface waters. However, the low abundance of omeprazole TPs in the H2O samples together with the fact that omeprazole suffers an extensive metabolism, with a wide range of excretion rates (between 0.01 and 30)̂, suggests that human urinary metabolites should be studied in the H2O environment. The results obtained in excretion tests after administration of a 40 mg omeprazole dose in 3 healthy volunteers are reported. Anal. by liquid chromatog. coupled to hybrid quadrupole time-of-flight mass spectrometry (LC-QTOF MS) reported low concentrations of omeprazole in urine. Up to 20-four omeprazole metabolites (OMs) were detected and tentatively elucidated. The most relevant OM was an omeprazole isomer, which obviously presented the same exact mass (m/z 346.1225), but also shared a major common fragment at m/z 198.0589. Subsequent analyses of surface H2O and effluent wastewater samples by both LC-QTOF MS and LC-MS/MS with triple quadrupole revealed that this metabolite (named as OM10) was the compound most frequently detected in H2O samples, followed by OM14a and OM14b. Up to the knowledge, OM10 had not been used before as urinary biomarker of omeprazole in waters. On the contrary, parent omeprazole was never detected in any of the H2O samples. After this research, it seems clear that monitoring the presence of omeprazole in the aquatic environment should be focused on the OMs suggested in this article instead of the parent compound The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Recommanded Product: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole

The Article related to omeprazole metabolite wastewater surface water urine analysis sample pollution, metabolites, omeprazole, time-of-flight mass spectrometry, triple quadrupole mass spectrometry, urine, water samples and other aspects.Recommanded Product: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On October 1, 2021, Bubyrev, Andrey; Adamchik, Maria; Darin, Dmitry; Kantin, Grigory; Krasavin, Mikhail published an article.COA of Formula: C6H11N3 The title of the article was Metal-Free Three-Component Synthesis of 1,2,3-Triazoline-4-Sulfonamides. And the article contained the following:

A new type of diazo compounds, namely, CH-diazomethane sulfonamides (generated in situ from readily available α-acetyl-α-diazomethane sulfonamides MeC(O)C(=N2)S(O)2NRR1 [R = Me; R1 = Ph, Bn, 4-fluorophenyl; RR1 = -(CH2)4-, -(CH2)2O(CH2)2-]) was employed in a 1,3-dipolar cycloaddition reaction with imines (also formed in situ from primary amines R2NH2 (R2 = n-Bu, cyclopentyl, morpholino, etc.) and aldehydes R3CHO (R3 = cyclopropyl, Ph, pyridin-3-yl, etc.)). The reaction gave hitherto undescribed 1,5-disubstituted 1,2,3-triazolin-4-yl sulfonamides I which were obtained in good to excellent yields and complete trans-diastereoselectivity. Oxidative aromatization of 1,2,3-triazolin-4-yl sulfonamides by manganese(IV) oxide gave nearly quant. yields of 1,2,3-triazol-4-yl sulfonamides II of which only two examples have been reported in the literature. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).COA of Formula: C6H11N3

The Article related to triazolyl sulfonamide preparation, triazolinyl sulfonamide preparation diastereoselective oxidative aromatization, acetyl diazomethane sulfonamide amine aldehyde three component dipolar cycloaddition and other aspects.COA of Formula: C6H11N3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On December 2, 2016, Youn, So Won; Kim, Yi Hyun published an article.Name: 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one The title of the article was Pd(II)/Ag(I)-Promoted One-Pot Synthesis of Cyclic Ureas from (Hetero)Aromatic Amines and Isocyanates. And the article contained the following:

A simple and facile one-pot reaction has been developed to afford a diverse range of N,N’-disubstituted benzimidazolones and imidazopyridinones containing two differently substituted N atoms. A cooperative Pd(II)/Ag(I) system promotes the sequential addition/intramol. C-H amidation reaction of (hetero)aromatic amines and isocyanates, leading to the formation of two C-N bonds. A mechanism involving radical intermediates generated by single-electron transfer (SET) in the presence of a Ag2CO3 oxidant and Pd(OAc)2 Lewis acid is proposed. This protocol offers an operationally easy, simple, and robust approach with the use of readily available starting materials, good functional group tolerance, and high efficiency. The experimental process involved the reaction of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one(cas: 41010-50-8).Name: 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

The Article related to disubstituted benzimidazolone imidazopyridinone preparation palladium silver promoted sequential reaction, cyclic urea preparation addition amidation hetero aromatic amine isocyanate and other aspects.Name: 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On December 15, 2022, Liu, Lin; Wu, Yan; Song, Ru; Zhang, Yu; Ma, Yafei; Wan, Jun; Zhang, Meili; Cui, Huali; Yang, Hua; Chen, Xiaoli; Wang, Jijiang published an article.Formula: C6H11N3 The title of the article was Morphology engineering and photothermal effect derived from perylene diimide based derivative for boosting photocatalytic hydrogen evolution of ZnIn2S4. And the article contained the following:

The construction of excellent photocatalysts for splitting water into hydrogen is highly desirable to realize carbon neutralization. In this work, an innovative and well-designed S-scheme photocatalyst composed of ultrathin ZnIn2S4 (ZIS) nanosheets uniformly anchored on the surface of organic semiconductor PDIIM is successfully fabricated. Within the heterojunction, perylene diimide with an imidazole group (PDIIM) is strategically applied as a structure template, which plays a crucial role in optimizing the morphol., increasing the active sites of sulfur vacancies, providing the addnl. photothermal effect, and promoting photogenerated charge separation of the catalyst. The photocatalytic H2 generation rate of the ZIS/PDIIM heterojunction with an optimized mass ratio reaches up to 13.04 mmol/g/h, which is 2.64 times and 14.02 times higher than that of pristine ZIS and PDIIM, resp. The outstanding photocatalytic activity is attributed to the synergistic effect of the above advantages. Importantly, the photothermal effect induced by PDIIM belonging to the perylene diimide-based derivative was discovered to accelerate photocatalytic H2 generation for the first time. This work provides valuable insight into the utilization of perylene diimide-based derivatives in the construction of multi-effect enhancement photocatalysts and their application in photothermal-assisted photocatalytic hydrogen evolution. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Formula: C6H11N3

The Article related to indium zinc sulfide perylene diimide hydrogen evolution reaction catalyst, organic semiconductor, perylene diimide, photocatalytic hydrogen evolution, photothermal effect, znin(2)s(4) and other aspects.Formula: C6H11N3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On November 15, 2017, Cook, James; Zusi, F. Christopher; Hill, Matthew D.; Fang, Haiquan; Pearce, Bradley; Park, Hyunsoo; Gallagher, Lizbeth; McDonald, Ivar M.; Bristow, Linda; Macor, John E.; Olson, Richard E. published an article.Name: 4-Bromo-1H-benzo[d]imidazol-2(3H)-one The title of the article was Design and synthesis of a novel series of (1’S,2R,4’S)-3H-4′-azaspiro[benzo[4,5]imidazo[2,1-b]oxazole-2,2′-bicyclo[2.2.2]octanes] with high affinity for the α7 neuronal nicotinic receptor. And the article contained the following:

We describe an efficient and convergent synthesis of a series of (1’S,2R,4’S)-3H-4′-azaspiro[benzo[4,5]imidazo[2,1-b]oxazole-2,2′-bicyclo[2.2.2]octanes], such as I (R = H, 5-Cl, 6-Me, etc.) displaying potency for the α7 nicotinic acetylcholine receptor (nAChR) and good selectivity vs. the related 5-HT3A receptor. The experimental process involved the reaction of 4-Bromo-1H-benzo[d]imidazol-2(3H)-one(cas: 40644-16-4).Name: 4-Bromo-1H-benzo[d]imidazol-2(3H)-one

The Article related to azaspiro benzoimidazooxazole bicyclooctane preparation alpha 7 nicotinic acetylcholine receptor, 5-ht(3a) receptor, schizophrenia, spirooxazolines, α7 nicotinic acetylcholine receptor and other aspects.Name: 4-Bromo-1H-benzo[d]imidazol-2(3H)-one

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On March 15, 2020, Huo, Siqi; Yang, Shuang; Wang, Jun; Cheng, Jianwen; Zhang, Qianqian; Hu, Yefa; Ding, Guoping; Zhang, Qiaoxin; Song, Pingan published an article.Name: N-(3-Aminopropyl)-imidazole The title of the article was Liquid phosphorus-containing imidazole derivative as flame-retardant curing agent for epoxy resin with enhanced thermal latency, mechanical, and flame-retardant performances. And the article contained the following:

The development of phosphorus-containing flame retardants combining good compatibility with matrix, low curing temperature, and mech. reinforcing effect has remained a major challenge. Herein, we reported the synthesis of a liquid flame-retardant curing agent (DA) via the nucleophilic substitution between diphenylphosphinic chloride and 1-(3-aminopropyl)-imidazole (AI). DA exhibited good blending and latency towards epoxy resin (EP) at room temperature According to DSC studies, DA could rapidly cure EP at moderate temperature Compared with EP/AI sample, EP/DA samples displayed comparable or higher glass transition temperature (Tg) and enhanced mech. properties due to the introduction of rigid diphenylphosphinyl group and improved crosslinking d. Moreover, DA improved the flame-retardant performances of EP thermoset. For instance, the LOI and UL94 rating of EP/DA-16 sample achieved 37.2% and V-0, resp. In addition, the peak of heat release rate (PHRR), average of heat release rate (AHRR), fire growth rate (FIGRA), and total heat release (THR) for EP/DA-16 sample reduced by 32%, 42%, 28% and 27% in comparison to EP/AI sample, resp. DA was characterized by its good compatibility with EP, moderate curing temperature, fast curing rate, suitable thermal latency, mech. reinforcing and flame-retardant effects, and thus it had a broad application prospect in various industrial fields. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Name: N-(3-Aminopropyl)-imidazole

The Article related to epoxy resin liquid phosphorus imidazole thermal latency flame retardancy, epoxy resin, flame retardancy, liquid phosphorus-containing imidazole, mechanical properties, thermal latency and other aspects.Name: N-(3-Aminopropyl)-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On January 31, 1992, Debnath, Asim Kumar; Lopez de Compadre, Rosa L.; Shusterman, Alan J.; Hansch, Corwin published an article.Electric Literature of 5709-67-1 The title of the article was Quantitative structure-activity relationship investigation of the role of hydrophobicity in regulating mutagenicity in the Ames test: 2: Mutagenicity of aromatic and heteroaromatic nitro compounds in Salmonella typhimurium TA100. And the article contained the following:

A quant. structure-activity relationship (QSAR) is derived for the mutagenic activity of 117 aromatic and heteroaromatic nitro compounds acting on S. typhimurium TA100. Relative mutagenic activity is bilinearly dependent on hydrophobicity, with an optimal log P of 5.44, and is linearly dependent on the energy of the LUMO of the nitro compound The dependence of mutagenic activity on hydrophobicity and electronic effects is very similar for TA98 and TA100. Mutagenic activity in TA100 does not depend on the size of the aromatic ring system, as its does in TA98. The effect of the choice of assay organism, TA98 vs. TA100, on nitroarene QSAR is similar to the effect previously found for aminoarenes. Lateral verification of QSARs is presented as a tool for establishing the significance of a new QSAR. The experimental process involved the reaction of 2-Nitro-1H-benzo[d]imidazole(cas: 5709-67-1).Electric Literature of 5709-67-1

The Article related to hydrophobicity qsar mutagenicity heteroaromatic nitro compound, structure aromatic nitro compound mutagenicity hydrophobicity, salmonella aromatic nitro compound mutagenicity structure and other aspects.Electric Literature of 5709-67-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Clark, Robert L.; Pessolano, Arsenio A.; Shen, Tsung-Ying; Jacobus, David P.; Jones, Howard; Lotti, Victor J.; Flataker, Lars M. published an article in 1978, the title of the article was Synthesis and analgesic activity of 1,3-dihydro-3-(substituted phenyl)imidazo[4,5-b]pyridin-2-ones and 3-(substituted phenyl)-1,2,3-triazolo[4,5-b]pyridines.Quality Control of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one And the article contains the following content:

One hundred-thirty imidazo[4,5-b]pyridin-2-ones (I, R = H or alkyl, X = H, halo, alkyl, NH2, etc.) and 60 triazolo[4,5-b]pyridines (II, X = H, halo, alkyl, alkoxy, NO2, etc.) were prepared, eg by cyclizing 3-nitro-2-anilinopyridines with COCl2, urea, or NaNO2. I and II increased the pain threshold of both the inflammed and the normal foot in a modified Randall-Selitto test. I (R = H, X = 3,4-OCH2O), I (R = allyl, X = 3,4-OCH2O), I (R = CHMe2, X = 3,4-OCH2O), II (X = H) and II (X = F) were the most active compounds The analgesic activity of I was superior to that of codeine or D-propoxyphene, while showing no narcotic characteristics. Some I and II were effective in the carrageenin edema test. The experimental process involved the reaction of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one(cas: 41010-50-8).Quality Control of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

The Article related to phenylimidazopyridinone preparation analgesic, phenyltriazolopyridine preparation analgesic, imidazopyridinone phenyl preparation analgesic, triazolopyridine phenyl preparation analgesic and other aspects.Quality Control of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem