Zhao, Chao-Yang published the artcilePd-Catalyzed Redox Divergent Coupling of Ketones with Terpenols, Recommanded Product: 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, the publication is ACS Catalysis (2021), 11(12), 6825-6834, database is CAplus.
A Pd-catalyzed redox divergent coupling of ketones e.g., 6,7,8,9-tetrahydro-5H-benzocyclohepten-5-one with terpenols like trans-geraniol, (E,E)-farnesyl alc. and (E)-phytol has been developed to access α-substituted ketones, e.g., 6-isopentyl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-one with varying degrees of unsaturation The control of oxidation states of the product is facilitated by employing different additives. With the aid of BnOH as an external hydrogen source, a reductive coupling pathway is thermodynamically favored. The use of LiBr as the additive will reduce the reactivity of Pd-H to divert the selectivity toward α,β-unsaturated ketones. By switching the solvent from toluene to chlorobenzene, the active species Pd-H will be fully quenched to enable oxidative coupling. Gram-scale reaction with lower catalyst loading (0.5 mol%) was also accomplished to highlight the practicability of this protocol. Furthermore, detailed exptl. studies were carried out to elucidate the reaction mechanism and the factors enabling manipulation of the redox selectivity. This redox divergent coupling protocol provides an important complement for known precedents on Tsuji-Trost allylation of ketones.
ACS Catalysis published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C10H11FN2O2S, Recommanded Product: 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride.
Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem