Wang, Yun's team published research in Journal of the American Chemical Society in 131 | CAS: 359860-27-8

Wang, Yun published the artcileA Click Chemistry Mediated in Vivo Activity Probe for Dimethylarginine Dimethylaminohydrolase, SDS of cas: 359860-27-8, the publication is Journal of the American Chemical Society (2009), 131(42), 15096-15097, database is CAplus and MEDLINE.

Asym. N^ω,N^ω-dimethyl-L-arginine (ADMA) is an endogenously produced inhibitor of human nitric oxide synthase and an emerging biomarker for cardiovascular disease. Concentrations of ADMA are controlled by two isoforms of its catabolic enzyme dimethylarginine dimethylaminohydrolase (DDAH), the dysregulation of which has been studied as a mediating factor for endothelial dysfunction. A two-part, click-chem. mediated activity-based probe, N-but-3-ynyl-2-chloroacetamidine, is shown to label myc-tagged DDAH-1 expressed in HEK 293T cells, but not an inactive mutant or inhibited enzyme. A two-color Western blotting technique is used to determine the in vivo IC₅₀ value for a reversible inhibitor of DDAH-1, N⁵-(1-iminopropyl)-L-ornithine, indicating this compound’s bioavailability and its competition for binding to the active site. This probe provides a novel tool for the anal. of DDAH-1 activity in normal and pathophysiol. states and should allow more meaningful studies of the etiol. of endothelial dysfunction.

Journal of the American Chemical Society published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C8H14O4, SDS of cas: 359860-27-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem