Tulecki, Jerzy published the artcileSynthesis of Bunte salts, isothiourea derivatives, and thioethers with expected radioprotective activity. XL, Recommanded Product: 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, the publication is Acta Poloniae Pharmaceutica (1977), 34(4), 359-69, database is CAplus and MEDLINE.
The thiosulfate I was prepared (77% yield) as the Na salt by heating equimol amounts of Na2S2O3 and 2-chloroacetylamino-6-carbomethoxybenzothiazole in H2O. Other Na or K salts of RS2O3H [R = PrCH(CONHCONH2), 3,4-(HO)2C6H3COCH2, PhO2CCH2, 2-HOC6H4COCH2, 4-IC6H4NHCOCH2, 4-IC6H4NHCOCH2CH2, 2-IC6H4NHCOCH2, 2-IC6H4NHCOCH2CH2, 5-uracilmethyl, 6-methyl-5-uracilmethyl] were prepared analogously in 42-75% yields. Treatment of 6-methyl-5-chloromethyluracil with thiourea in absolute EtOH yielded 88% II-HCl. Analogously were prepared (52-80% yields) other RSC(:NH)NH2.HCl from 1-methyl- and 1-ethyl-2-chloromethylbenzimidazole, 5-chloromethyluracil, and N-(3-chloropropionyl)-2-iodoaniline. 4-Chloroquinoline 1-oxide added to a solution of 4-ClC6H4SH in EtONa-EtOH yielded 70% III (R = 4-ClC6H4). Other III were prepared analogously (54-89% yields) from 4-Me3CC6H4SH, 2-naphthalenethiol, 2-mercapto-N-(2-naphthyl)acetamide, 2-mercaptobenzothiazole, and 2-mercaptobenzoxazole.
Acta Poloniae Pharmaceutica published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C5H10O, Recommanded Product: 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole.
Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem