Radwanska, A. published the artcileComparative analysis of effects of imidazoline drugs on isolated rat heart atria, SDS of cas: 2508-72-7, the publication is Journal of Physiology and Pharmacology (1993), 44(1), 73-87, database is CAplus and MEDLINE.
Effects of cumulative concentrations of 16 known imidazoline and 2 imidazole drugs on amplitude and rate of spontaneously beating isolated rat heart atria were measured and related to the resp. effects induced by norepinephrine. In addition, the effects of fixed concentrations of the agents on the responses evoked by cumulative concentrations of norepinephrine were determined In general, imidazolines classified as α1-adrenoceptor agonists showed pos. inotropic activity providing evidence of involvement of the α1-adrenoceptor in mediating cardiac contractility. A neg. chronotropic effect was common for the imidazolines studied, including α1-adrenoceptor agonists, α2-adrenoceptor agonists, α1/α2-adrenoceptor antagonists and antazoline – an antihistaminergic imidazolkine devoid of adrenoceptor affinity. On the other hand, the imidazole derivative, medetomidine, showed a weak pos. chronotropic activity. Neg. chronotropic properties appeared to be independent of the alpha-adrenoceptors and may result from the membrane stabilizing action, involving probably the sodium channel blockage.
Journal of Physiology and Pharmacology published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, SDS of cas: 2508-72-7.
Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem