Coston, Alain published the artcileTest of reserpine-induced pontogeniculooccipital spikes in the cat, Computed Properties of 2508-72-7, the publication is Journal de Pharmacologie (1976), 7(3), 409-14, database is CAplus.
The effects of various psychotropic agents on reserpine [50-55-5]-induced pontogeniculooccipital (PGO) spikes were studied in cats. Tricyclic antidepressants dose-dependently antagonized reserpine with clomipramine-HCl [17321-77-6] having the greatest effect. Phenelzine bisulfate [156-51-4] also inhibited reserpine activity. Of the antihistaminics studied dexchlorpheniramine maleate [2438-32-6] and mepyramine maleate [59-33-6] caused the greatest decrease in PGO spikes but were less effective than clomipramine. Orphenadrine-HCl [341-69-5] decreased PGO spikes while dopa [59-92-7] had no effect. A marked decrease in PGO points was also observed with chlordiazepoxide [58-25-3]. Thus, the response of reserpine-induced PGO spikes is an effective means of studying the effects of antidepressants on central reserpine [50-55-5] uptake.
Journal de Pharmacologie published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Computed Properties of 2508-72-7.
Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem