Badhani, Gaurav published the artcileIonic-Liquid-Catalyzed Synthesis of Imines, Benzimidazoles, Benzothiazoles, Quinoxalines and Quinolines through C-N, C-S, and C-C Bond Formation, Safety of 1,2-Diphenyl-1H-benzo[d]imidazole, the publication is European Journal of Organic Chemistry (2021), 2021(48), 6705-6716, database is CAplus.
The tetra-Me ammonium hydroxide catalyzed oxidative coupling of amines RNH2 (R = Ph, cyclohexyl, pentyl, etc.) and alcs. R1CH2OH (R1 = Ph, 4-pyridyl, 2-naphthyl, etc.) for the synthesis of imines RN=CHR1 under metal-free conditions by utilizing oxygen from air as the terminal oxidant has been described. Under the same conditions, with ortho-phenylene diamines 1,2-(NH2)2C6H3R2 (R2 = 3-Me, 4,5-(Me)2, 4-F, etc.) and 2-aminobenzenethiols like 2-aminobenzenethiol and 2-amino-4-chlorobenzenethiol the corresponding benzimidazoles I (R3 = 6-Me, 5,6-Me2, 5-Cl, etc.; X = NH) and benzothiazoles I (R3 = H, 5-Cl; X = S) were obtained. Quinoxalines II (R4 = H, 6-Me, 6,7-Me2, 6-Cl, 6-F; Y = N) were obtained from ortho-phenylene diamines and 1-phenylethane-1,2-diol, and the conditions were then extended to the synthesis of quinoline building blocks II (R4 = 4-ClC6H4, 4-BrC6H4, 4-MeOC6H4, 2-naphthyl; Y = CH) by reaction of 2-amino benzyl alcs. like 2-aminobenzenemethanol either with 1-phenylethan-1-ol or acetophenone derivatives R4COMe. The formation of C-N, C-S and C-C bonds was achieved under metal-free conditions. A broad range of amines (aromatic, aliphatic, cyclic and heteroaromatic) as well as benzylic alcs. including heteroaryl alcs. reacted smoothly and provided the desired products. The mild reaction conditions, com. available catalyst, metal-free, good functional-group tolerance, broad range of products (imines, benzimidazoles, benzothiazoles, quinoxalines and quinolines) and applicability at gram scale reactions are the advantages of the present strategy.
European Journal of Organic Chemistry published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C19H14N2, Safety of 1,2-Diphenyl-1H-benzo[d]imidazole.
Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem