Synthesis and preliminary evaluation of curcumin analogues as cytotoxic agents was written by Zhang, Qin;Zhong, Ying;Yan, Lin-Na;Sun, Xun;Gong, Tao;Zhang, Zhi-Rong. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2011.Electric Literature of C11H10N2O2 The following contents are mentioned in the article:
A series of curcumin analogs with different substituents at the 4-position of the Ph group were synthesized and screened for in vitro cytotoxicity against a panel of human cancer cell lines. Several novel curcumin analogs, especially I and II, exhibited selective and potent cytotoxic activity against human epidermoid carcinoma cell line A-431 and human glioblastoma cell line U-251, implying their specific potential in the chemoprevention and chemotherapy of skin cancer and glioma. The preliminary SAR information extracted from the results suggested that introduction of appropriate substituents to the 4′-positions could be a promising approach for the development of new cytotoxic curcumin analogs with special selectivity for A-431 and U-251 cell lines. This study involved multiple reactions and reactants, such as 4-(1H-Imidazol-1-yl)-3-methoxybenzaldehyde (cas: 870837-70-0Electric Literature of C11H10N2O2).
4-(1H-Imidazol-1-yl)-3-methoxybenzaldehyde (cas: 870837-70-0) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Electric Literature of C11H10N2O2
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem