2-Aldehydes of imidazo[4,5-b]- and imidazo[4,5-c]pyridines was written by Yutilov, Yu. M.;Kovaleva, L. I.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1975.Application In Synthesis of 2,3-Dimethyl-3H-imidazo[4,5-c]pyridine The following contents are mentioned in the article:
Imidazopyridinecarboxaldehydes (I, R = Me, PhCH2, Ph, R1 = CHO), II (R1 = CHO), III (R1 = CHO), and IV (R = PhCH2, Ph, R1 = CHO) were obtained in 50-84% yields by oxidation of the corresponding 2-methyl derivative with SeO2 in dioxane at 70-80°. Condensation of the aldehydes with CH2(CO2H)2 gave 43-60% acrylic acid derivatives I (R = Me, R1 = CH:CHCO2H). II (R1 = CH:CHCO2H), and IV (R = Ph, R1 = CH:CHCO2H). The cyano derivatives I (R = Me, PhCH2R1 = CN), II (R1 = CN), and IV (R = PhCH2, Ph, R1 = CN) were obtained in 65-93% by boiling the corresponding aldoximes with Ac2O 7 hr. Amides I (R = Me, PhCH2, R1 = CONM2), II (R1 = CONH2), and IV (R = Ph, R1 = CONH2) were obtained in 60-82% yields by oxidation of the corresponding nitriles with concentrated H2SO4. This study involved multiple reactions and reactants, such as 2,3-Dimethyl-3H-imidazo[4,5-c]pyridine (cas: 52538-09-7Application In Synthesis of 2,3-Dimethyl-3H-imidazo[4,5-c]pyridine).
2,3-Dimethyl-3H-imidazo[4,5-c]pyridine (cas: 52538-09-7) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Application In Synthesis of 2,3-Dimethyl-3H-imidazo[4,5-c]pyridine
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem