One-pot oxidative conjugate hydrothiocyanation-hydrosulfenylation of Baylis-Hillman alcohols promoted by a protic ionic liquid was written by Yadav, Lal Dhar Singh;Patel, Rajesh;Srivastava, Vishnu Prabhakar. And the article was included in Synlett in 2008.Synthetic Route of C10H20N2O4S The following contents are mentioned in the article:
The first example of one-pot oxidative conjugate hydrothiocyanation-hydrosulfenylation of acrylic ester derived Baylis-Hillman alcs., i.e., Me 3-aryl-3-hydroxy-2-methylenepropanoate, was reported. The reaction involved protic ionic liquid [Hmim]HSO4-mediated oxidation of Baylis-Hillman alcs. with NaNO3 to give Me (E)-α-formylcinnamates followed by conjugate addition of sulfur-centered nucleophiles (NH4SCN/PhSH) to afford the corresponding Me β-thiocyanato (or β-phenylsulfenyl)-α-formylhydrocinnamates diastereoselectively in 74-87% yields in a one-pot procedure. After isolation of the product, the ionic liquid [Hmim]HSO4 could be easily recycled for further use without any loss of efficiency. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Synthetic Route of C10H20N2O4S).
1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Synthetic Route of C10H20N2O4S
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem