Prolonged shedding of infectious viruses with haplotype switches of SARS-CoV-2 in an immunocompromised patient was written by Shoji, Kosuke;Suzuki, Akira;Okamoto, Michiko;Tsinda, Emmanuel Kagning;Sugawara, Naoko;Sasaki, Mie;Nogami, Yoshihiko;Kobayashi, Michio;Oshitani, Hitoshi;Yanai, Masaru. And the article was included in Journal of Infection and Chemotherapy in 2022.SDS of cas: 16506-27-7 The following contents are mentioned in the article:
A concern has been raised that the persistent COVID-19 infection in an immunocompromised host can be the source of the SARS-CoV-2 variants. This is the case of a 61-yr-old man in complete remission of a follicular lymphoma after six cycles of rituximab and bendamustine with addnl. two cycles of rituximab completed eight months prior to the episode of COVID-19 pneumonia. The patients respiratory failure was long-lasting, and required mech. ventilation until day 75. Acquired immunity tested neg. throughout the observational period. The viral RNA was detectable until day 100 while the infectious virus was isolated until day 79. Seven haplotypes were identified and the non-synonymous mutations accumulated in the spike gene which included E484Q and S494P. In the management of COVID-19 cases with suppressed immune statuses, initial evaluation of existing immunity and monitoring for infectiousness throughout the clin. course including the convalescent stage may be necessary. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7SDS of cas: 16506-27-7).
4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.SDS of cas: 16506-27-7
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem