Cooperative binding and stepwise encapsulation of drug molecules by sulfonylcalixarene-based metal-organic supercontainers was written by Sheng, Tian-Pu;Fan, Xin-Xia;Zheng, Guo-Zong;Dai, Feng-Rong;Chen, Zhong-Ning. And the article was included in Molecules in 2020.Related Products of 117976-90-6 The following contents are mentioned in the article:
The cooperative binding behavior of a face-directed octahedral metal-organic supercontainer featuring one endo cavity and six exo cavities was thoroughly examined in chloroform solution through UV-visible (UV-Vis) titration technique using two representative drug mols. as the guests. The titration curves and their nonlinear fit to Hill equation strongly suggest the efficient encapsulation of the guest mols. by the synthetic host, which exhibit interesting cooperative and stepwise binding behavior. Based on the control experiments using tetranuclear complex as a reference, it is clear that two equivalent of the guest mols. are initially encapsulated inside the endo cavity, followed by the trapping of six addnl. equivalent of the drug mols. through six exo cavities (1 equivalent per exo cavity), and the remaining guests are entrapped by the external pockets. The results provide an in-depth understanding of the cooperative binding behavior of metal-organic supercontainers, which opens up new opportunities for designing synthetic receptors for truly biomimetic functional applications. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Related Products of 117976-90-6).
Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Related Products of 117976-90-6
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem