Cyclometalated 2-Phenylimidazole Palladium Carbene Complexes in the Catalytic Suzuki-Miyaura Cross-Coupling Reaction was written by Micksch, Maik;Tenne, Mario;Strassner, Thomas. And the article was included in Organometallics in 2014.Electric Literature of C21H24N2 The following contents are mentioned in the article:
We present the syntheses of cyclometalated palladium C-N 2-phenylimidazole carbene complexes with different N-1 groups as well as different substituents at the C-2 Ph group of the cyclometalating imidazole. We investigated the influence of these substituents by comparing the catalytic performance of the complexes in the Suzuki-Miyaura cross-coupling reaction of aryl chlorides. We can show a strong dependence between the steric demand of the N-1 substituent of the cyclometalating imidazole and the catalytic activity in the cross-coupling reaction. The most active complex shows a wide substrate scope, where several aryl as well as benzyl chlorides could be coupled with different boronic acids in excellent yields using very low catalyst concentrations of 0.05 mol %. This study involved multiple reactions and reactants, such as 1-(2,6-Diisopropylphenyl)-2-phenyl-1H-imidazole (cas: 914306-50-6Electric Literature of C21H24N2).
1-(2,6-Diisopropylphenyl)-2-phenyl-1H-imidazole (cas: 914306-50-6) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Electric Literature of C21H24N2
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem