Synthesis of 1,2-diaryl- and 1-aryl-2-alkylimidazoles with sterically demanding substituents was written by Micksch, Maik;Tenne, Mario;Strassner, Thomas. And the article was included in European Journal of Organic Chemistry in 2013.Electric Literature of C21H24N2 The following contents are mentioned in the article:
1,2-Diarylimidazoles are an important class of compounds They are frequently used as ligands for photophys. active metal complexes and also display physiol. activity. We developed a new, high-yielding procedure for the synthesis of 1,2-diaryl-substituted imidazoles with sterically demanding substituents at the resp. ortho positions by starting from com. available anilines and benzoic acids through the corresponding acid chlorides. The metal-free method provides access to a variety of different substituents on the Ph rings at N-1 and C-2 as well as at the 4,5-positions of the imidazole backbone. Our new method is also suitable for the preparation of 1-aryl-2-alkylimidazoles. This study involved multiple reactions and reactants, such as 1-(2,6-Diisopropylphenyl)-2-phenyl-1H-imidazole (cas: 914306-50-6Electric Literature of C21H24N2).
1-(2,6-Diisopropylphenyl)-2-phenyl-1H-imidazole (cas: 914306-50-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Electric Literature of C21H24N2
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem