A Simple and Practical Synthesis of 2-Aminoimidazoles was written by Little, Thomas L.;Webber, Stephen E.. And the article was included in Journal of Organic Chemistry in 1994.Name: 4-Phenyl-1H-imidazol-2-amine hemisulfate The following contents are mentioned in the article:
A new and simple two-step procedure to synthesize 2-aminoimidazoles (2-AI’s) from readily available materials has been developed. The cyclization reaction of α-halo ketones RCOCHR1X [R = Me, Et, CMe3, Ph, 4-BrC6H4, etc., R1 = H, Me, Ph, RR1 = (CH2)3, (CH2)4, X = Cl, Br] and N-acetylguanidine in acetonitrile (MeCN) at reflux, or in DMF at ambient temperature, gives 4(5)-substituted and 4,5-disubstituted N-(1H-imidazol-2-yl)acetamides I, which are then hydrolyzed to their resp. 2-AI’s. In general, the purified products were isolated in good yields. We have prepared several examples and have demonstrated the usefulness of this method by its application in the total synthesis of 2-aminohistamine, an interesting histamine analog, and oroidin (II), a marine natural product isolated from various sponges. This study involved multiple reactions and reactants, such as 4-Phenyl-1H-imidazol-2-amine hemisulfate (cas: 160072-56-0Name: 4-Phenyl-1H-imidazol-2-amine hemisulfate).
4-Phenyl-1H-imidazol-2-amine hemisulfate (cas: 160072-56-0) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Name: 4-Phenyl-1H-imidazol-2-amine hemisulfate
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem