The preventive effect of two coordination polymers in the treatment of hypotension after uterine oviduct and ovarian surgery was written by Li, Chang-Kun;Ren, Xiao-Jing;Zhang, Jing-Yi;Zheng, Zhong-Lei;Du, Ke-Xin. And the article was included in Latin American Journal of Pharmacy in 2022.Synthetic Route of C11H9N5 The following contents are mentioned in the article:
In the current study, via using the mixed-ligand synthesis approach, two new Cu(II) and Co(II)-containing coordination polymers (CPs) with the chem. compositions of {[Cu2(L)[H(1,4-bmib)]]·1.5(H2O)}n (11, 1,4-bmib = 1,4-bis(2-methylimidazol-1-yl)butane) and {[Co2(HL)(3,5-bip)2]·(H2O)}n (2, 3,5-bip = 3,5-bis(1-imidazolyl) pyridine) have been successfully prepared by reaction of the corresponding metal salts with the flexible carboxylic ligand 3,5-bis(3,5-dicarboxylphenoxy)benzoic acid (H5L) in the presence of different N-donor co-ligands. Furthermore, the biol. activity of compounds 1 and 25 on the hypotension after uterine oviduct and ovarian surgery was evaluated and the related mechanism was explored at the same time. Firstly, the blood pressure of the hypotension animal model was measured. Besides, the relative expression of the α receptors on peripheral small blood vessels was determined with real time RT-PCR assay. This study involved multiple reactions and reactants, such as 3,5-Di(1H-imidazol-1-yl)pyridine (cas: 1374155-84-6Synthetic Route of C11H9N5).
3,5-Di(1H-imidazol-1-yl)pyridine (cas: 1374155-84-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Synthetic Route of C11H9N5
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem