The Syntheses, Structures, Fluorescence Properties and Biological Activity of two Novel Zinc(II) Complexes Controlled by the Tripodal Imidazole Ligand was written by Gao, En-Jun;Zhang, Shaozhong;Meng, Yang;Zhao, Fu-Chen;Ma, Xiao-Yu;Jin, Hai-Tao;Liu, Si-Jia;Ge, Jing;Sun, Ya-Guang;Zhang, Wan-zhong;Zhu, Ming-Chang. And the article was included in Journal of Fluorescence in 2016.Product Details of 1374155-84-6 The following contents are mentioned in the article:
Two new zinc complexes, namely Zn(L1)ClCH2NO(1) and {Zn(L2)CH2NO}n N(CH3)3 ClO4(2) (L1 = 3,5-di(1H-imidazol-1-yl)pyridine L2 = 1,3,5-tris(1-imidazolyl) benzene), have been synthesized, and characterized by IR spectra, elemental anal., and a single crystal X-ray diffraction. Fluorescence spectroscopy indicated that two complexes presented strong DNA binding affinity constants to fish sperm DNA (FS-DNA). Gel electrophoresis assay demonstrated the ability of the complex to cleave the HL-60 DNA. Apoptotic study showed the complex exhibited significant cancer cell(KB) inhibitory rate. This study involved multiple reactions and reactants, such as 3,5-Di(1H-imidazol-1-yl)pyridine (cas: 1374155-84-6Product Details of 1374155-84-6).
3,5-Di(1H-imidazol-1-yl)pyridine (cas: 1374155-84-6) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Product Details of 1374155-84-6
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem