Stereoselective and nonstereoselective pharmacokinetics of rabeprazole – an overview was written by Dash, Ranjeet Prasad;Rais, Rana;Srinivas, Nuggehally R.. And the article was included in Xenobiotica in 2018.Electric Literature of C18H20N3NaO3S The following contents are mentioned in the article:
A review. Proton pump inhibitors have been extensively used for the treatment of ailments due to increased gastric acid secretion such as peptic ulcers, gastroesophageal reflux disease, etc. There are several approved drugs in the proton pump inhibitor class with the latest entries representing single enantiomer drugs of the previously approved racemic drugs. Despite having a high degree of structural resemblance, rabeprazole, was shown to possess some unique differentiation from other drugs in the class. One of the key distinguishing features of rabeprazole was related to the lesser involvement of polymorphic metabolism in its pharmacokinetic disposition. The review was aimed to provide pharmacokinetic data of rabeprazole from several clin. studies including drug-drug interaction studies where rabeprazole was either a perpetrator drug or victim drug. Addnl. perspectives on therapy considerations due to the unique metabolic disposition of rabeprazole including the possible issues related to chirality were provided. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Electric Literature of C18H20N3NaO3S).
Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Electric Literature of C18H20N3NaO3S
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem