Repurposing of pharmaceutical drugs by high-throughput approach for antihypertensive activity as inhibitors of angiotensin-converting enzyme (ACE) using HPLC-ESI-MS/MS method was written by Bhatti, Muhammad Salman;Asiri, Yahya Ibrahim;Uddin, Jalal;El-Seedi, Hesham R.;Musharraf, Syed Ghulam. And the article was included in Arabian Journal of Chemistry in 2021.Electric Literature of C18H20N3NaO3S The following contents are mentioned in the article:
Angiotensin-converting enzyme (ACE) plays an important role in regulating blood pressure in the body by converting angiotensin-I into angiotensin-II. It is the basic component of Renin angiotensin aldosterone system (RAAS), imbalance of RAAS may leads to many cardiovascular and renal diseases. There are many marketed available drugs for the inhibition of ACE, but prolonged use of some drugs may cause the progressive side effects. Repurposing of existing drugs can be a way to find new inhibitors of ACE. In this study, a high-throughput and sensitive method of HPLC-ESI-QqQ-MS with good reproducibility (%RSD < 9.98) and linearity (R2 = 0.999) was used to investigate the 77 com. drugs for their inhibitory potential as antihypertensive drugs. Among these drugs, 41 drugs were found active and 36 of them showed moderate to good inhibition with lowest IC50 = 272 μM. This study showed that different pharmaceutical drugs can also be used as ACE inhibitor after necessary clin. trials or validation. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Electric Literature of C18H20N3NaO3S).
Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Electric Literature of C18H20N3NaO3S
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem