New method for synthesis of 2-hetaryl-substituted imidazo[4,5-b]pyridine and imidazo[4,5-c]pyridine was written by Yutilov, Yu. M.;Kovaleva, L. I.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1977.Reference of 52538-09-7 The following contents are mentioned in the article:
Imidazopyridines I [X = Y = CH, Z = N, R = 6-methyl-2-pyridyl (II), 2-quinolyl (III), imidazo [4,5-c] pyridin-2-yl (IV), R1 = H; X = N, Y = Z = CH, R = II, 2-benzothiazolyl, 2-benzimidazoyl, III, 1-methylimidazo[4,5-c]pyridin-2-yl, R1 = Me; X = Z = CH, Y = N, R = IV, R1 = Me] were obtained in 83-98% yields by treatment of the corresponding diaminopyridine V with MeR 3-8h at 165-200°. This study involved multiple reactions and reactants, such as 2,3-Dimethyl-3H-imidazo[4,5-c]pyridine (cas: 52538-09-7Reference of 52538-09-7).
2,3-Dimethyl-3H-imidazo[4,5-c]pyridine (cas: 52538-09-7) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Reference of 52538-09-7
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem