Effectiveness of ibrutinib as first-line therapy for chronic lymphocytic leukemia patients and indirect comparison with rituximab-bendamustine: Results of study on 486 cases outside clinical trials was written by Morabito, Fortunato;Tripepi, Giovanni;Del Poeta, Giovanni;Mauro, Francesca Romana;Reda, Gianluigi;Sportoletti, Paolo;Laurenti, Luca;Coscia, Marta;Herishanu, Yair;Bossio, Sabrina;Varettoni, Marzia;Murru, Roberta;Chiarenza, Annalisa;Visentin, Andrea;Condoluci, Adalgisa;Moia, Riccardo;Pietrasanta, Daniela;Loseto, Giacomo;Consoli, Ugo;Scortechini, Ilaria;Rossi, Francesca Maria;Zucchetto, Antonella;Al-Janazreh, Hamdi;Vigna, Ernesto;Martino, Enrica Antonia;Cassin, Ramona;D’Arrigo, Graziella;Galimberti, Sara;Rago, Angela;Angeletti, Ilaria;Biagi, Annalisa;Del Giudice, Ilaria;Bomben, Riccardo;Neri, Antonino;Fronza, Gilberto;Monti, Paola;Menichini, Paola;Olivieri, Jacopo;Cutrona, Giovanna;Rossi, Davide;Cuneo, Antonio;Di Raimondo, Francesco;Gaidano, Gianluca;Polliack, Aaron;Trentin, Livio;Foa, Robin;Ferrarini, Manlio;Gattei, Valter;Gentile, Massimo. And the article was included in American Journal of Hematology in 2021.SDS of cas: 16506-27-7 The following contents are mentioned in the article:
However, these biomarkers’ practical prognostic relevance in the era of new drugs remains an open issue. Results investigating the clin. impact of IB in the current clin. practice mainly focused so far on relapsedresistant (RR) patients. Here, we conducted a multicenter, retrospective study to ascertain the predictive and prognostic relevance of well-known biol. and clin. indicators in 165 patients treated with IB as first-line. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7SDS of cas: 16506-27-7).
4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.SDS of cas: 16506-27-7
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem