Zhu, Mingchang et al. published their research in Applied Organometallic Chemistry in 2019 | CAS: 1374155-84-6

3,5-Di(1H-imidazol-1-yl)pyridine (cas: 1374155-84-6) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.COA of Formula: C11H9N5

Two MnII, CuII complexes derived from 3,5-bis(1-imidazolyl)pyridine: Synthesis, DNA binding, Molecular docking and cytotoxicity studies was written by Zhu, Mingchang;Liu, Jiaxing;Su, Junqi;Meng, Bo;Feng, Yunhui;Jia, Bing;Peng, Tingting;Qi, Zhenzhen;Gao, Enjun. And the article was included in Applied Organometallic Chemistry in 2019.COA of Formula: C11H9N5 The following contents are mentioned in the article:

Two complexes [MnL2(H2O)2]路2ClO4 (complex 1) and [CuL(H2O)3]路2NO3 (complex 2) (L = 3,5-bis(1-imidazolyl)pyridine) were designed and synthesized. The structures of the complexes were characterized by x-ray crystallog., elemental analyses, and IR spectra. The interaction capacity of the complexes with calf thymus DNA was studied by UV and fluorescence spectroscopy. Gel electrophoresis assay demonstrated the ability of the complexes to cleave the pBR322 plasmid DNA. Efficient binding properties of DNA were established by UV-visible, fluorescence, and gel electrophoresis. The intrinsic binding constants (Kb) are 0.1524 and 0.1041 for complexes 1 and 2, resp. The two complexes exhibited a higher cytotoxicity against HeLa cell lines and lower cytotoxicity toward normal cell lines. Flow cytometry demonstrated the cancer cell inhibitory rate of the two complexes. Computer-aided mol. docking studies were performed to visualize the binding mode of the drug candidate at the mol. level. Complex 1 exhibited a significant higher cancer cell inhibitory rate than cisplatin and other complexes. This study involved multiple reactions and reactants, such as 3,5-Di(1H-imidazol-1-yl)pyridine (cas: 1374155-84-6COA of Formula: C11H9N5).

3,5-Di(1H-imidazol-1-yl)pyridine (cas: 1374155-84-6) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.COA of Formula: C11H9N5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem