Impact of rabeprazole sodium on pharmacokinetics of nimesulide in healthy volunteers: a prospective study from Pakistan was written by Munir, Iqra;Aslam, Bilal;Naseer, Rana Dawood;Mahmood, Asif;Saleem, Uzma;Sultana, Aisha;Muneer, Saiqa;Abrar, Muhammad Asad;Ashraf, Mudassar. And the article was included in Acta Poloniae Pharmaceutica in 2018.COA of Formula: C18H20N3NaO3S The following contents are mentioned in the article:
Nimesulide is mostly being prescribed along proton pump inhibitors such as rabeprazole sodium to reduce gastric irritation and damage. Therefore, present study was aimed to evaluate the effect of rabeprazole sodium on the pharmacokinetics of nimesulide in healthy adult male volunteers. Healthy volunteers (n = 30) participated in this study. After overnight fasting, blood samples (5 mL) were withdrawn at predetermined time intervals i.e. 0, 1, 1.5, 2, 2.5, 3, 4, 6, 8, 10, 12 h. After washout period of 15 days, Nimesulide was co-administered with rabeprazole sodium to the same volunteers and blood samples were taken again. Plasma concentration of nimesulide was determined by using HPLC technique. Pharmacokinetic parameters were determined by using pharmacokinetic software APO, MW/PHRAM version 3.02. Results showed that rabeprazole sodium increased the Cmax of nimesulide from 1.21 卤 0.27 mg/L to 1.79 卤 0.18 mg/L and AUC was increased from 12.96 卤 1.34 mg/L.h to 17.46 卤 1.54 mg/L.h. Clearance and Vd of nimesulide were decreased. Elevated plasma levels of nimsulide were observed due to enzymic inhibition effect of rabeprazole sodium. Impact of nimsulide on pharmacokinetics of rabeprazole was successfully determined The knowledge regarding drug – drug interaction would be beneficial for the researchers, health care professionals and patients. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6COA of Formula: C18H20N3NaO3S).
Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.COA of Formula: C18H20N3NaO3S
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem