Enantioseparation and modelling study of six proton pump inhibitors on a novel 3, 5-dichloro-phenylcarbamated 尾-cyclodextrin chemically bonded chiral stationary phase by high performance liquid chromatography was written by Li, Meng;Jiang, Zhen;Guo, Xingjie;Di, Xin;Yu, Jia. And the article was included in Microchemical Journal in 2021.Application In Synthesis of Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide The following contents are mentioned in the article:
A fully substituted 尾-cyclodextrin derivative chem. bonded chiral stationary phase for high performance liquid chromatog., named MDCPC was prepared by linking 3, 5-dichloro-phenylcarbamated mono-6-ethylenediamine-尾-cyclodextrin to the surface of silica support. The as-prepared MDCPC was successfully characterized by SEM, fourier transform IR spectra, solid state NMR spectra, elemental anal. and thermogravimetric anal. The enantioselectivity of MDCPC was systematically evaluated by using proton pump inhibitors including omeprazole, lansoprazole, pantoprazole sodium, ilaprazole, rabeprazole sodium and tenatoprazole under the normal phase, polar organic phase, and reversed phase conditions. Effects of the mobile phase compositions and buffers on enantioseparation were investigated in different modes. As a result, MDCPC showed a better chromatog. performance in enantioselectivity, and all tested compounds were successfully enantiosepd. Findings of the mol. docking showed that hydrogen bonding, hydrophobic interaction and inclusion complexation played an important role in improving enantioselectivity. Addnl., good repeatability, column-to-column reproducibility and stability of MDCPC were observed by the study of chiral or achiral separation As a novel chiral stationary phase, MDCPC was supposed to be a promising prospect in the further anal. of chiral drugs. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Application In Synthesis of Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide).
Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Application In Synthesis of Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem