Comparative in vitro drug release examination of dissimilar brands of Rabeprazole sodium gastro-resistant tablets was written by Yarra, Shravani;Abdul ahad, Hindustan;Haranath, Chinthaginjala;Musa, Gamaa birir mohamed;Adam, Adam ali omer;Reddy, Kethari rushiketh. And the article was included in International Journal of Life Science and Pharma Research in 2020.Synthetic Route of C18H20N3NaO3S The following contents are mentioned in the article:
The present work was aimed to test the relative physicochem. and in vitro drug release properties of some popular enteric coated brands of Rabeprazole sodium tablets marketed in India. The generic drugs should accept challenges on par with patent innovative drug mols. in the in vitro evaluation parameters. Six different Indian brands of Rabeprazole sodium tablets (marketed in India) with a strength of 20 mg were purchased from the market and they were judged for uniformity of weight, thickness, diameter, hardness, disintegration time, drug content, and in vitro release. The disintegration time and in-vitro drug release studies were examined in 0.1M HCl (for 2h) and buffer solution of pH 6.8 (till drug dissolves). The evaluated brands of the Rabeprazole sodium tablets passed all the tests conducted as per the pharmacopoeial standards and comply in all the parameters. All the brands represented their resistance to disintegrate/dissolve the stomach environment (2h) and disintegrate/dissolve in the intestinal environment (within 1h). The dissolution summary revealed that the Rabeprazole sodium tablet brand (RST-1) was faster while Rabeprazole sodium tablet brand (RST-2) was slower, and the remaining brands of Rabeprazole sodium showed identical results. The authors conclude from the study that all the brands evaluated for all physicochem. constraints including in vitro dissolution are satisfactory and identical with each other, and patients can take any of these brands as prescribed by the physician. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Synthetic Route of C18H20N3NaO3S).
Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Synthetic Route of C18H20N3NaO3S
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem