Wang, Rui published the artcileDetermination of antazoline hydrochloride in rat plasma and excreta by reversed-phase ion-pair chromatography and its application to pharmacokinetics, COA of Formula: C17H20ClN3, the publication is Biomedical Chromatography (2013), 27(12), 1595-1602, database is CAplus and MEDLINE.
A reversed-phase ion pair chromatog. method with liquid-liquid extraction anal. method was developed and validated for the determination of antazoline hydrochloride in plasma and excreta of rat. The aim of our study was to characterize the preclin. pharmacokinetics and excretion profiles of antazoline hydrochloride in rats after i.v. injection at the dose of 10 mg/kg. Plasma and excreta samples were extracted with Et acetate, and phenacetin was used as the internal standard The result showed that the method is suitable for the quantification of antazoline hydrochloride in plasma and excreta samples. Anal. of accuracy (90.89-112.33%), imprecision (<7.1%) and recovery (>82.5%) showed adequate values. After a single i.v. administration at 10 mg/kg to rats, plasma concentration profile showed a relative fast elimination proceeding with a terminal elimination half-life of 3.53 h. Approx. 61.8 and 14.2% of the administered dose were recovered in urine and bile after 72 and 24 h post-dosing resp.; 5.9% of the administered dose was recovered in feces after 72 h post-dosing. The above results show that the major elimination route is urinary excretion. Copyright © 2013 John Wiley & Sons, Ltd.
Biomedical Chromatography published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C18H34N4O5S, COA of Formula: C17H20ClN3.
Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem