Van Santvliet, L. published the artcilePhysicochemical properties, NMR spectroscopy and tolerance of inclusion complexes of antazoline and tetracaine with hydroxypropyl-β-cyclodextrin, Related Products of imidazoles-derivatives, the publication is International Journal of Pharmaceutics (1998), 171(2), 147-156, database is CAplus.
To improve the tolerance of antazoline and tetracaine ophthalmic solutions, inclusion complexes of the free bases of both drugs with hydroxypropyl-β-cyclodextrin (HP-β-CD) were prepared The physicochem. properties of the drug:HP-β-CD solutions were determined and the inclusion complexes were characterized by 1H and 13C NMR spectroscopy. The apparent complex constants were calculated from the phase-solubility diagram and were estimated at 403 M-1 and 1308 M-1 for the antazoline:HP-β-CD complex and tetracaine:HP-β-CD complex, resp. NMR anal. showed that in the 1:1 complexes the total antazoline fraction was present as an inclusion complex, whereas tetracaine was only partly included in spite of a similar phase solubility diagram. NMR spectroscopy also revealed the site of interaction of the drugs with the HP-β-CD mol. A solution acceptability test was carried out on volunteers. A relationship between the surface tension of the solutions and the tolerance was observed
International Journal of Pharmaceutics published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C10H10O2, Related Products of imidazoles-derivatives.
Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem