Marszall, Michal Piotr published the artcileReduction of silanophilic interactions in liquid chromatography with the use of ionic liquids, Synthetic Route of 2508-72-7, the publication is Analytica Chimica Acta (2005), 547(2), 172-178, database is CAplus.
A suppression of silanophilic interactions by the selected ionic liquids added to the mobile phase in thin-layer chromatog. (TLC) and HPLC is reported. Acetonitrile was used as the eluent, alone or with various concentrations of water and phosphoric buffer pH 3. Selectivity of the normal (NP) and the reversed (RP) stationary phase material was examined using proton-acceptor basic drugs analytes. The ionic liquids studied appeared to significantly affect analyte retention in NP-TLC, RP-TLC and RP-HPLC systems tested. Consequently, the increased separation selectivity was attained. Due to ionic liquid additives to eluent even analytes could be chromatographed, which were not eluted from the silica-based stationary phase materials with 100% of acetonitrile in the mobile phase. Addition of ionic liquid already in very small concentration (0.5%, volume/volume) could reduce the amount of acetonitrile used during the optimization of basic analytes separations in TLC and HPLC systems. Also, the influence of temperature on the separation of basic analytes was demonstrated and considered in practical HPLC method development.
Analytica Chimica Acta published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Synthetic Route of 2508-72-7.
Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem