Hagedorn, Alfred A. III published the artcileCardiotonic agents. 2. (Imidazolyl)aroylimidazolones, highly potent and selective positive inotropic agents, Application of 4-((1H-Imidazol-1-yl)methyl)benzoic acid, the main research area is imidazolylaroylimidazolone preparation inotropic activity; cardiac phosphodiesterase inhibition imidazolylbenzoylimidazolone; mol structure inotropic activity.
Twenty-two alkyldihydro[(imidazolyl)benzoyl]imidazolones (e.g., I; R = Me, R1 = H) was synthesized and evaluated in vitro for pos. inotropic and cAMP phosphodiesterase inhibitory activity. Thus, the imidazolone II was heated at 140° in molten imidazole to give 61% I (R = Me, R1 = H). A wide range of inotropic and enzyme-inhibitory potencies was observed, substitution on the imidazolyl moiety being the major determinant of activity. I (R = Et, R1 = H) exhibited the highest potency in vitro. Incorporation of a Me group at the imidazolyl 2-position gave I (R = Et, R1 = Me), which was less potent but remarkably selective in vivo for pos. inotropic effects over heart rate and hypotensive effects.
Journal of Medicinal Chemistry published new progress about Heart. 94084-75-0 belongs to class imidazoles-derivatives, name is 4-((1H-Imidazol-1-yl)methyl)benzoic acid, and the molecular formula is C11H10N2O2, Application of 4-((1H-Imidazol-1-yl)methyl)benzoic acid.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem