Yamada, Junji published the artcileParticipation of peroxisomal β-oxidation system in the chain-shortening of a xenobiotic acyl compound, SDS of cas: 94084-75-0, the main research area is drug metabolism liver beta oxidation; peroxisome function drug metabolism.
A model drug, (E)-3-[4-(1-imidazolylmethyl)phenyl]-2-propenoic acid [82571-53-7], was metabolized to 4-(1-imidazolylmethyl)benzoic acid [94084-75-0] by isolated hepatocytes of rats and this metabolism was enhanced by pretreatment of rats with clofibrate. With liver homogenates, the formation of the CoA-ester [94666-06-5] of this drug and its subsequent chain-shortening were demonstrated. Acyl-CoA synthetase [9013-18-7], CoA [85-61-0], ATP [56-65-5], and NAD [53-84-9] were required for this metabolic sequence; CN- did not inhibit the reaction. These results indicate that peroxisomes are capable of shortening the acyl side-chains of drugs by the β-oxidation, giving an addnl. suggestion on the functions of peroxisomes.
Biochemical and Biophysical Research Communications published new progress about Alkyl groups. 94084-75-0 belongs to class imidazoles-derivatives, name is 4-((1H-Imidazol-1-yl)methyl)benzoic acid, and the molecular formula is C11H10N2O2, SDS of cas: 94084-75-0.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem