Meshcheryakova, S. A. published the artcileSynthesis of new thietanylpyrimidine and thietanylimidazole derivatives, Synthetic Route of 18874-52-7, the main research area is pyrimidine chloromethylthiirane alkylation rearrangement; chloromethylthiirane imidazole alkylation rearrangement; thietane pyrimidine preparation; imidazole thietane preparation.
New thietanyl-substituted derivatives of pyrimidine-2,4(1H,3H)-dione and imidazole were synthesized. The alkylation of 6-methylpyrimidine-2,4(1H,3H)-diones with 2-(chloromethyl)thiirane in water involved N(1) of the pyrimidine ring and afforded 6-methyl-1-(thietan-3-yl)pyrimidine-2,4(1H,3H)-diones. Under analogous conditions, 6-aminopyrimidine-2,4(1H,3H)-dione gave 6-(thietan-3-ylamino)pyrimidine-2,4(1H,3H)-dione. Unsym. substituted 2-methyl-4(5)-nitro- and 5(4)-bromo-2-methyl-4(5)-nitro-1H-imidazoles reacted with 2-(chloromethyl)thiirane to produce mixtures of isomeric 2-methyl-4(5)-nitro-1-(thietan-3-yl)-1H-imidazoles and 5(4)-bromo-2-methyl-4(5)-nitro-1-(thietan-3-yl)-1H-imidazoles.
Russian Journal of Organic Chemistry published new progress about Alkylation. 18874-52-7 belongs to class imidazoles-derivatives, name is 5-Bromo-2-methyl-4-nitroimidazole, and the molecular formula is C4H4BrN3O2, Synthetic Route of 18874-52-7.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem