Kirk, Kenneth L. published the artcileBiochemistry and pharmacology of ring-fluorinated imidazoles, Recommanded Product: 5-Fluoro-1H-imidazole, the main research area is fluoroimidazole pharmacol; histadine fluoro derivative pharmacol; imidazole fluoro derivative pharmacol.
Concentrations of 2-fluorohistidine (I) [57212-36-9] ≤10-5 M were bacteriostatic with Escherichia coli, but the inhibition was reversed by the addition of L-histidine [71-00-1]. I also showed antiviral activity in cell cultures. Thyrotropin-releasing-factor (TRF) [24305-27-9] and luteinizing hormone-releasing factor (LHRF) [9034-40-6] were synthesized with I and 4-fluorohistidine [57372-70-0] residues as replacement for the histadine residues; while the 4-fluoro analogs were inactive, those containing I showed 20-30% activity. 4-Fluorohistadine did not show bacterostatic or antiviral activity, but it was a substrate for bacterial histidine decarboxylase [9024-61-7]. Neither 4-fluorourocanic acid [60010-44-8] or 2-fluorourocanic acid [60010-46-0] was a substrate for urocanase [9014-58-8], but the 2-fluoro derivative of urocanic acid was an inhibitor of the enzyme. 2-Fluorohistamine [50581-18-5] had good affinity for H1 histamine receptors in guinea pig ileum.
ACS Symposium Series published new progress about Antihistamines. 30086-17-0 belongs to class imidazoles-derivatives, name is 5-Fluoro-1H-imidazole, and the molecular formula is C3H3FN2, Recommanded Product: 5-Fluoro-1H-imidazole.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem