Kim, Moon H. published the artcileThe design, synthesis, and biological evaluation of potent receptor tyrosine kinase inhibitors, Product Details of C10H7ClN2O, the main research area is indolinone derivative preparation antitumor receptor tyrosine kinase inhibitor pharmacokinetic.
Variously substituted indolin-2-ones were synthesized and evaluated for activity against KDR, Flt-1, FGFR-1 and PDGFR. Extension at the 5-position of the oxindole ring with Et piperidine (I) proved to be the most beneficial for attaining both biochem. and cellular potencies. Further optimization of I to balance biochem. and cellular potencies with favorable ADME/ PK properties led to the identification of II, a compound with a clean CYP profile, acceptable pharmacokinetic and toxicity profiles, and robust efficacy in multiple xenograft tumor models.
Bioorganic & Medicinal Chemistry Letters published new progress about Angiogenesis. 62457-94-7 belongs to class imidazoles-derivatives, name is (4-Chlorophenyl)(1H-imidazol-2-yl)methanone, and the molecular formula is C10H7ClN2O, Product Details of C10H7ClN2O.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem