Dolensky, Bohumil published the artcileSynthesis of 4,5-difluoroimidazole, Formula: C3H3FN2, the main research area is imidazole difluoro preparation; photochem Schiemann reaction aminoimidazole fluorination.
5-Fluoroimidazole-4-carboxylic acid Et ester 3 was converted to the corresponding hydrazide 4 in 81% yield. Oxidation of the hydrazide to the carbonyl azide 5 (88%) and Curtius rearrangement in t-Bu alc. produced 94% 4-t-butyloxycarbonylamino-5-fluoroimidazole 6. Dissolution of the t-Bu carbamate in 50% HBF4, in situ diazotization of the resulting amine, and irradiation produced the target compound 1 in 36% yield from 6 by the photochem. Schiemann reaction.
Journal of Fluorine Chemistry published new progress about Curtius reaction. 30086-17-0 belongs to class imidazoles-derivatives, name is 5-Fluoro-1H-imidazole, and the molecular formula is C3H3FN2, Formula: C3H3FN2.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem