Volynets, Galyna published the artcileIdentification of protein kinase fibroblast growth factor receptor 1 (FGFR1) inhibitors among the derivatives of 5-(5,6-dimethoxybenzimidazol-1-yl)-3-hydroxythiophene-2-carboxylic acid, Application of 5,6-Dimethoxy-1H-benzo[d]imidazole, the main research area is dimethoxy benzimidazolyl hydroxythiophene carboxylate preparation FGFR1 inhibitor cancer.
Abstract: Fibroblast growth factor receptor 1 (FGFR1) plays an important role in tumorigenesis, suggesting that inhibitors of this protein kinase may become important compounds for the development of anticancer agents. Using mol. docking approach, we have identified a novel class of FGFR1 inhibitors belonging to the derivatives of 5-(5,6-dimethoxybenzimidazol-1-yl)-3-hydroxythiophene-2-carboxylic acid. It was revealed that the most promising compound 5-(5,6-dimethoxybenzimidazol-1-yl)-3-[2-(methanesulfonyl)benzyloxy]thiophene-2-carboxylic acid Me ester inhibits FGFR1 with an IC50 value of 150 nM in in vitro kinase assay. The structure-activity relationships have been studied, and the binding mode of this chem. class has been proposed. Graphic abstract: [Figure not available: see fulltext.].
Monatshefte fuer Chemie published new progress about Antitumor agents. 72721-02-9 belongs to class imidazoles-derivatives, name is 5,6-Dimethoxy-1H-benzo[d]imidazole, and the molecular formula is C9H10N2O2, Application of 5,6-Dimethoxy-1H-benzo[d]imidazole.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem